自噬在结核分枝杆菌感染中作用的研究进展  

The Research Progress of Autophagy in Mycobacterium tuberculosis Infection

作　　者：马沁梅 韩璐[1,2] 邓光存[1,2] 吴晓玲[1,2] MA Qinmei;HAN Lu;DENG Guangcun;WU Xiaoling(Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China,Yinchuan 750021,China;School of Life Sciences,Yinchuan 750021,China)

机构地区：[1]西部特色生物资源保护与利用教育部重点实验室,银川750021 [2]宁夏大学生命科学学院,银川750021

出　　处：《中国细胞生物学学报》2019年第9期1797-1804,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31760324、31760326);宁夏重点研发计划项目(批准号:2018BFH03017);西部一流学科建设重大创新项目(批准号:ZKZD2017001);宁夏科技创新领军人才培养项目(批准号:KJT2017002)资助的课题~~

摘　　要：结核病是一种由结核分枝杆菌感染引发的全球致死性传染病。结核分枝杆菌感染巨噬细胞后其在胞内的命运与细胞自噬的发生息息相关。但是,由于结核分枝杆菌与细胞自噬之间的博弈过程十分复杂且机制尚未完全阐明。因此,该文以结核分枝杆菌感染巨噬细胞后经典自噬和LAP对结核病发生发展的作用为切入点,从自噬抗结核分枝杆菌感染与结核分枝杆菌破坏自噬发生两个方面阐述了自噬与结核分枝杆菌之间的相互作用,从而为结核病发病机制的研究提供新的思路和视角。The infection of Mycobacterium tuberculosis(Mtb)is the cause of tuberculosis(TB),which remains a fatal rate in most parts of the world.The mechanism of the interaction between Mtb and host cell is complicated and unclear.Moreover,the fate of Mtb and macrophage are related with autophagy.In this context,we summarize current knowledge about the role of autophagy in Mtb infection.By mostly morphological and mechanically studies,it showed that autophagy can effectively suppress Mtb infection to macrophage.Oppositely,Mtb break the autophagic process by self-protection.In light of the interaction between autophagy and Mycobacterium tuberculosis,it provides novel insights for studying pathogensis and physiological control of tuberculosis.

关 键 词：结核病 结核分枝杆菌 巨噬细胞 细胞自噬 

分 类 号：R52[医药卫生—内科学]