尼古丁影响机体代谢的分子机制研究进展  

Advances in Researches of Molecular Mechanisms of Nicotine Affecting Metabolisms

作　　者：雷自立 迟作华[2] 杨艳红[2] LEI Zili;CHI Zuohua;YANG Yanhong(Institute of Chinese Medicinal Sciences,Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;The First Affiliated Hospital/School of Clinical Medicine,Guangdong Pharmaceutical University,Guangzhou 510080,China)

机构地区：[1]广东药科大学中医药研究院,广东省代谢病中西医结合研究中心,广州510006 [2]广东药科大学附属第一医院/临床医学院,广州510080

出　　处：《中国细胞生物学学报》2019年第9期1813-1821,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81803912、31671520);广东省中医药局科研项目(批准号:20182079);广东省教育厅特色创新类项目(自然科学)广东药科大学“创新强校工程”资助项目(批准号:2017KTSCX102);广州市越秀区科技计划项目(批准号:2018-WS-011、2017-WS-004)资助的课题~~

摘　　要：吸烟可以引起糖脂代谢紊乱及导致胰岛素抵抗等,而戒烟可以增加体重,但吸烟影响机体代谢的具体分子机制仍不清楚。该文对香烟主要成分尼古丁通过AMPK信号通路、炎症及凋亡相关信号通路等影响机体代谢的分子机制进行了归纳与总结,为今后进一步研究尼古丁在代谢性疾病防治中的作用提供科学依据。Smoking can cause disorders of glucose and lipid metabolism,and lead to insulin resistance.Smoking cessation can increase body weight,but the molecular mechanisms of smoking affecting metabolism is still unclear.In this review,the molecular mechanisms of nicotine affecting metabolism through AMPK signaling pathway,inflammation and apoptosis-related signaling pathways were summarized and discussed,which would provide scientific basis for further research on the role of nicotine in the prevention and treatment of metabolic diseases in the future.

关 键 词：尼古丁 AMPK信号通路 胰岛素抵抗 炎症 凋亡 

分 类 号：R16[医药卫生—公共卫生与预防医学]