类沸石咪唑酯骨架(ZIFs)及其复合物在药物递送系统中的应用  

Application of Zeolitic Imidazolate Frameworks(ZIFs) and Their Complexes in Drug Delivery Systems

作　　者：赵悦竹 张薇薇[1] 付庆辉 杨亚妮[1] 何军[1] ZHAO Yuezhu;ZHANG Weiwei;FU Qinghui;YANG Yani;HE Jun(National Pharmaceutical Engineering and Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203)

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心

出　　处：《中国医药工业杂志》2019年第11期1256-1261,共6页Chinese Journal of Pharmaceuticals

摘　　要：金属有机骨架材料(metal organic frameworks,MOFs)是一类无机化合物;类沸石咪唑酯骨架结构材料(zeolitic imidazolateframeworks,ZIFs)作为其亚簇,具有孔径大、稳定性好、比表面积大、生物相容性好等优点。ZIFs的特殊结构性质使其具有作为药物载体的潜力,如可装载抗肿瘤药物达到肿瘤部位并响应微环境特点进行释药等。本文综述了ZIFs及其复合物在药物递送方面,特别是抗肿瘤药方面的应用原理及其前景。Metal organic frameworks(MOFs) are a class of inorganic compounds, and zeolitic imidazolate frameworks(ZIFs) as sub-clusters of MOFs have the advantages of large pore size, good stability, high specific surface area, and good biocompatibility. These special properties make ZIFs and their complexes to be the potential drug carriers, which can encapsulate and deliver anti-tumor drugs to tumor sites and triggered release in response to acidic environment. This paper focuses on the application and prospect of ZIFs and their complexes in antitumor therapy.

关 键 词：金属有机骨架材料 类沸石咪唑酯骨架结构材料 类沸石咪唑酯骨架结构材料复合物 药物递送系统 抗肿瘤药 

分 类 号：R944.9[医药卫生—药剂学] TH145.1[医药卫生—药学]