早期益生菌肠内营养对感染性休克患者营养状态和临床疗效的影响  

Effect of early probiotic enteral nutrition on nutritional status and clinical efficacy in the patients with septic shock

作　　者：项美姣[1] 葛国平[1] XIANG Meijiao;GE Guoping(ICU,Jinhua People's Hospital in Zhejiang Province,Jinhua 321000,China)

机构地区：[1]浙江省金华市人民医院ICU

出　　处：《中国现代医生》2019年第31期18-21,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划（2019KY748）

摘　　要：目的探讨早期益生菌肠内营养对感染性休克患者营养状态及临床疗效的影响。方法选取我院2017年1月~2018年12月接诊的感染性休克患者64例,按照随机数字排列法将其分为两组,每组32例,对照组采用常规营养治疗,观察组采用早期益生菌肠内营养干预,观察两组患者治疗前后营养状况[血清白蛋白(Alb)、总蛋白(TP)、血红蛋白(Hb)]以及炎症因子[血清白细胞介素(IL-6、IL-8)以及肿瘤坏死因子-α(TNF-α)]变化情况。结果两组患者干预后Alb、TP、Hb均低于干预前,观察组干预后Alb、TP、Hb高于对照组(P<0.05);两组患者干预后IL-6、IL-8、TNF-α均低于干预前,观察组干预后IL-6、IL-8、TNF-α低于对照组(P<0.01)。两组干预后APACHEⅡ评分均低于干预前,干预后观察组APACHEⅡ评分低于对照组(P<0.05)。结论早期益生菌肠内营养干预可改善患者营养状态及炎症因子水平。Objective To investigate the effects of early probiotic enteral nutrition on nutritional status and clinical efficacy in the patients with septic shock. Methods 64 patients with septic shock who were admitted to our hospital from January 2017 to December 2018 were selected and randomly divided into two groups according to the random number method, with 32 patients in each group. The control group was given conventional nutritional therapy, and the observation group was given early probiotic enteral nutritional intervention. The changes in nutritional status [serum albumin(Alb),total protein(TP), hemoglobin(Hb)] and inflammatory factors [serum interleukin(IL-6, IL-8), and tumor necrosis factor-α(TNF-α)] were observed before and after treatment in the two groups. Results Alb, TP and Hb were lower in the two groups after intervention than those before intervention. Alb, TP and Hb after intervention were higher in the observa tion group than in the control group(P<0.05);IL-6, IL-8 and TNF-α were lower after intervention in the two groups than those before intervention. IL-6, IL-8 and TNF-α after intervention were lower in the observation group than in the control group(P<0.01). The APACHE Ⅱ scores in the two groups after intervention were lower than those before intervention. The APACHE Ⅱ score in the observation group after intervention was lower than that in the control group(P<0.05). Conclusion Early probiotic enteral nutritional intervention can improve the nutritional status and inflammato ry factors of patients.

关 键 词：感染性休克 早期益生菌肠内营养 营养状态 炎症因子 

分 类 号：R459.7[医药卫生—急诊医学]