抗梅毒治疗和RPR滴度对梅毒孕妇妊娠结局的影响  

Effect of Anti-syphilis Treatment and RPR Titer on Pregnancy Outcome in pregnant women with syphilis

作　　者：吕宣艳[1] Lu Xuan-yan(Department of Outpatient,Xinyi City Center for Disease Control and Prevention,Xinyi,Jiangsu Province,221400 China)

机构地区：[1]江苏省新沂市疾病预防控制中心门诊部

出　　处：《系统医学》2019年第21期64-66,共3页Systems Medicine

摘　　要：目的对比不同抗梅毒治疗、不同RPR滴度对梅毒孕妇妊娠结局的影响。方法选择2016年5月—2018年3月中102例梅毒孕妇,接受规范治疗的患者40例视作1组,未接受规范治疗的32例视作2组,未接受治疗的30例视作3组,比较3组妊娠结局。结果1组孕妇不良妊娠结局发生率为2.50%,2组为15.63%,3组为43.33%,1组、2组、3组新生儿不良结局发生率为5.00%、21.88%、50.00%,差异有统计学意义(P<0.05);RPR滴度≥1:8的孕妇,接受规范治疗后所产新生儿RPR滴度明显更低,差异有统计学意义(P<0.05);3组新生儿出生后不同时间RPR滴度转阴率,差异有统计学意义(P<0.05)。结论对梅毒孕妇开展规范化治疗有助于妊娠结局的明显改善,梅毒孕妇RPR滴度越高,新生儿先天性梅毒发生风险越高。Objective To compare the effects of different anti-syphilis treatments and different RPR titers on the pregnancy outcome of pregnant women with syphilis.Methods 102 pregnant women with syphilis were selected from May 2016 to March 2018.40 patients who received standard treatment were treated as group A,32 patients who did not receive standard treatment were treated as group B,and 30 patients who did not receive treatment were treated as 30 patients.In the 3 groups,the pregnancy outcomes of the 3 groups were compared.Results The incidence of adverse pregnancy outcome was 2.50%in group A,15.63%in group B,and 43.33%in group C.The incidence of adverse outcomes in neonates in group A,group B and group C was 5.00%,21.88%,50.00%,the difference was statistically significant P<0.05;pregnant women with RPR titer≥1:8 had significantly lower RPR titers in the neonates after standard treatment,the difference was statistically significant(P<0.05);there were statistical differences in the RPR titer between the three groups at different times after birth,with significance,the difference was statistically significant(P<0.05).Conclusion Standardized treatment of pregnant women with syphilis is helpful for the improvement of pregnancy outcome.The higher the RPR titer of pregnant women with syphilis,the higher the risk of congenital syphilis in neonates.

关 键 词：抗梅毒 治疗 RPR滴度 梅毒 孕妇 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]