血清Sestrin 2在子痫前期孕妇中的变化及诊断价值  

Serum Sestrin 2 concentration in preeclampsia pregnant women and its diagnostic value

作　　者：陈岚[1] 杨纯[1] 孟磊 CHEN Lan;YANG Chun;MENG Lei(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院西院妇产科,武汉430022 [2]华中科技大学同济医学院附属协和医院西院重症医学科,武汉430022

出　　处：《实用医学杂志》2019年第21期3296-3299,共4页The Journal of Practical Medicine

基　　金：国家自然科学青年基金项目(编号：81602277)

摘　　要：目的探讨子痫前期(preeclampsia,PE)和无并发症血压正常的健康孕妇血清Sestrin 2浓度变化及诊断价值。方法选取2018年1月至2019年1月于我院妇产科收治的PE患者60例,分为轻度PE组(30例)和重度PE组(30例),同期年龄、孕周和体质量指数(BMI)匹配的健康孕妇30例为对照组。采用ELISA法检测3组研究对象血清Sestrin 2浓度,Spearman相关分析血清Sestrin 2浓度与临床病理参数间关系,受试者操作曲线(ROC)分析血清Sestrin 2浓度对PE诊断价值。结果重度PE组孕妇的平均血压、蛋白尿、HELLP综合征检出率显著高于轻度PE组孕妇(P<0.01)。轻度PE组患者血清Sestrin 2浓度显著高于对照组[(0.933±0.35)ng/mL vs.(0.449±0.40)ng/mL,P<0.05],重度PE组血清Sestrin 2浓度显著高于轻度PE组孕妇[(1.891±4.83)ng/mL vs.(0.933±0.35)ng/mL,P<0.05]。血清Sestrin 2浓度与出生间隔呈负相关(r=-0.462,P=0.009),与新生儿体质量呈负相关(r=-0.387,P=0.006)。血清Sestrin 2浓度截断值为1.637 ng/mL时,其诊断PE患者的ROC曲线下面积(AUC)为0.737(95%CI:0.627~0.829,P<0.001),敏感性和特异性分别为64.2%和96.4%。结论PE孕妇血清Sestrin 2浓度显著高于健康孕妇,且随着PE严重程度增加而增加,与PE孕妇新生儿出生体重呈显著负相关,对PE具有一定诊断价值。Objective To investigate the serum concentration of Sestrin 2 in preeclampsia(PE)and healthy pregnant women and its diagnostic value.Methods 60 patients with PE in the department of obstetrics and gynecology of our hospital from January 2018 to January 2019 were enrolled.The patients were divided into mild PE group(30 cases)and severe PE group(30 cases)according to the severity of PE disease.Healthy pregnant women who are matched with age,gestational age and body mass index were recruited as control group.Serum Sestrin 2 concentration was measured by ELISA method.Spearman correlation analysis was used to analyze the relationship between serum Sestrin 2 concentration and clinicopathological parameters.The receiver operating curve(ROC)was used to analyze the diagnostic value of serum Sestrin 2 concentration in PE patients.Results Blood pressure,severe proteinuria,and HELLP syndrome were significantly higher in the severe PE group than in the mild PE patients(P<0.01).The serum Sestrin 2 concentration in PE patients was significantly higher than that in healthy pregnant women[(1.133±0.450)ng/mL vs.(0.449±0.400)ng/mL,P<0.05].Serum Sestrin 2 concentration in severe PE group was significantly higher than that in mild PE patients[(1.891±4.830)vs.(0.933±0.350)ng/mL,P<0.05].There was a negative correlation between serum Sestrin 2 level and birth intervals(r=-0.462,P=0.009),which was negatively correlated with neonatal weight(r=-0.387,P=0.006).The optimal cutoff value of serum Sestrin 2 concentration was 1.637 ng/mL,the area under the ROC curve(AUC)for patients diagnosed with PE was 0.737(95%CI:0.627~0.829,P<0.001),with sensitivity and specificity of 64.2% and 96.4%,respectively.Conclusion The serum concentration of Sestrin 2 in PE patients is significantly higher than that in healthy pregnant women,and it increases with the severity of PE.It is significantly negatively correlated with the birth weight of PE patients.It has certain diagnostic value for PE patients.

关 键 词：Sestrin 2 子痫前期 孕妇 诊断价值 

分 类 号：R71[医药卫生—妇产科学]