卷曲霉素治疗耐药结核病作用机制、毒副作用及耐药机制的研究进展  

Research Progress on Action Mechanism,Toxic and Side Effects,and Resistance Mechanism of Capreomycin in the Treatment of Drug Resistant Tuberculosis

作　　者：李秋阳 陈玲 LI Qiuyang;CHEN Ling(Tuberculosis Division,Department of Pulmonary and Critical Care Medicine,the Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)

机构地区：[1]遵义医科大学附属医院呼吸与危重症医学科结核病区

出　　处：《实用心脑肺血管病杂志》2019年第11期107-110,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目（81760003)

摘　　要：耐药结核病的出现给全球范围内结核病防控工作带来前所未有的挑战。耐药结核病需采用二线抗结核药物治疗,而卷曲霉素属注射类药物,是治疗耐药结核病的核心二线抗结核药物之一,但近年来卷曲霉素因耳毒性等毒副作用而在临床应用受限。本文对卷曲霉素治疗耐药结核病的作用机制、毒副作用及耐药机制等进行了综述,以期提高临床对卷曲霉素的认识并合理使用卷曲霉素。Emergence of drug resistant tuberculosis brings unprecedented challenge in global tuberculosis control.Drug resistant tuberculosis needs to be treated with the second-line anti-tuberculosis drugs,in which injectable capreomycin is one of core drugs,but the clinical application of capreomycin is limited due to its ototoxicity or other toxic and side effects.This paper reviewed the action mechanism,toxic and side effects,and resistance mechanism of capreomycin in the treatment of drug resistant tuberculosis,in order to improve the clinical acquaintance and rational usage of capreomycin.

关 键 词：结核 结核分枝杆菌 广泛耐药结核 卷曲霉素 突变 综述 

分 类 号：R52[医药卫生—内科学]