Fluid-Structure Interaction Simulation of Aqueous Outflow System in Response to Juxtacanalicular Meshwork Permeability Changes with a Two-Way Coupled Method  

作　　者：Jing Zhang Xiuqing Qian Haixia Zhang Zhicheng Liu 

机构地区：[1]School of Biomedical Engineering,Capital Medical University,Beijing,100069,China. [2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application,Capital Medical University,Beijing,100069,China. [3]College of Medical Imaging,Xuzhou Medical University,Xuzhou,221004,China.

出　　处：《Computer Modeling in Engineering & Sciences》2018年第8期301-314,共14页工程与科学中的计算机建模（英文）

基　　金：This work study is financially supported by the National Natural Science Foundation of China(Nos.31570952,10802053,81471702);the Natural Science Foundation of Beijing(No.3122010)。

摘　　要：Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system(AOS).However,there is still no consensus about exact location of the increased outflow resistance of aqueous humor,and the mechanism is not perfect.In addition,it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology.In this paper,a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork,juxtacanalicular meshwork(JCM)and Schlemm’s canal in response to JCM permeability changes.We obtained the JCM permeability of normal intraocular pressure varied between 1×10?15 m2 and 10×10?15 m2 while permeability of the JCM ranged from 2×10?16 m2 and 3×10?16 m2 under conditions of high intraocular pressure.The study indicated that the fluid dynamics parameters in trabecular meshwork and Schlemm’s canal are most significantly affected by the changes of JCM permeability.Moreover,the study demonstrates that the finite element modeling of AOS provides a practical means for studying the outflow dynamics and the biomechanical environment of the AOS.

关 键 词：Juxtacanalicular MESHWORK fluid-structure interaction PERMEABILITY TRABECULAR MESHWORK 

分 类 号：O64[理学—物理化学]