在中老年人群中2型糖尿病病程和FRAX评分之间相关性分析  

Relationship between the fracture risk by FRAX score and duration of diabetes in middle-aged and elder people with type 2 diabetes

作　　者：高远[1] 俞海燕[1] 郭晓珍[1] 张晓兰[1] 黄文龙[1] GAO Yuan;YU Haiyan;GUO Xiaozhen;ZHANG Xiaolan;HUANG Wenlong(Department of Endocrinology,the Affiliated Jiangyin People Hospital of Southeast Medical University,Wuxi 214400,China)

机构地区：[1]东南大学医学院附属江阴医院内分泌科

出　　处：《中国骨质疏松杂志》2019年第11期1542-1544,共3页Chinese Journal of Osteoporosis

基　　金：江阴市卫计委科研项目面上项目(M201504)

摘　　要：目的 探讨FRAX评分在与糖尿病病程之间的关系。 方法 选取278例糖尿病人群,并收集相关临床指标。通过FRAX公式计算2型糖尿病患者10年髋部骨折发生概率(PHF)和10年主要骨质疏松性骨折发生概率(PMOF)。研究2型糖尿病患者中FRAX与糖尿病病程之间的关系。 结果 发现随着糖尿病病程的延长,L 1-4 、股骨颈骨密度均无明显改变( P >0.05),而随着病程的增长,PMOF、PHF水平之间有区别,差异有统计学意义,且随着病程的延长两者呈逐渐增大的趋势( P <0.05)。 结论 糖尿病病程与10年骨质疏松性骨折发生概率之间有密切相关性。Objective To evaluate the relationship between the fracture risk by FRAX score and duration of diabetes. Methods A total of 278 people with type 2 diabetes were enrolled and their clinical data were collected. We evaluate the 10-year probability of hip fracture (PHF) and a major osteoporotic fracture (PMOF) using the FRAX algorithm in order to investigate association between FRAX score and duration of diabetes. Results Bone mineral density of the lumbar spine (L1-4) and the femoral neck (FN) in DM group increased with increasing of duration of type 2 diabetes ( P >0.05). However, with the increase of duration, there was gradually increasing trend in PMOF and PHF ( P <0.05). Conclusion There is close correlation among PHF, PMOF, and duration in type 2 diabetes.

关 键 词：骨质疏松 FRAX 2型糖尿病 

分 类 号：R58[医药卫生—内分泌]