结直肠炎合并关节病患者HLA-B27表达情况、VAS评分和ESR的相关性分析  

Correlation analysis of HLA-B27 expression,VAS score and ESR in patients with colitis and arthrosis

作　　者：李文清[1] 邓飞[1] 王福祖[1] 余大莲[1] LI Wenqing;DENG Fei;WANG Fuzu;YU Dalian(Department of Clinical Laboratory,Qinghai Hospital of traditional Chinese Medicine,Xining,Qinghai 810000,China)

机构地区：[1]青海省中医院检验科

出　　处：《国际检验医学杂志》2019年第23期2883-2886,共4页International Journal of Laboratory Medicine

摘　　要：目的探究结直肠炎合并关节病患者HLA-B27表达情况及其与视觉模拟评分(VAS)相关性。方法选取2016年1月至2019年1月该院诊治的结肠炎和/或直肠炎患者,将合并关节病和纳入条件的93例患者纳入观察组,选取同期同年龄段就诊的仅患结肠炎和/或直肠炎患者50例作为对照组,另外选取50例来于该院体检的健康人50例作为健康对照组。分别检测两组HLA-B27、VAS评分和红细胞沉降率(ESR)等指标,并按VAS评分对观察组进行再分组,分析各指标将差异。结果三组HLA-B27阳性率、VAS评分和ESR等指标比较,差异有统计学意义(P<0.05),其中观察组患者各指标水平最高,对照组其次,健康对照组最低;观察组HLA-B27阳性患者VAS评分明显高于HLA-B27阴性患者(P<0.05);对照组患者HLA-B27是否呈阳性与VAS分级分布无明显关联(P>0.05),且其VAS分级分布与观察组比较,差异有统计学意义(P<0.05);观察组HLA-B27阳性和阴性患者Kellgren-Lawrence分级分布比较,差异有统计学意义(P<0.05);对照组HLA-B27阳性和阴性患者患者Kellgren-Lawrence分级比较,差异无统计学意义(P>0.05),但均与观察组分布情况差异有统计学意义(P<0.05)。结论结直肠炎合并关节病患者中HLA-B27阳性表达水平异常,其阳性表达与关节受累有一定关联,即阳性表达患者VAS评分更高,受累关节疼痛更为明显。Objective To investigate the expression of HLA-B27 and its correlation with visual analogue score(VAS)in patients with colitis and arthrosis.Methods from January 2016 to January 2019,93 cases of colitis and/or proctitis patients with joint diseases and conditions were included in the observation group,50 cases of colitis and/or proctitis patients at the same age were selected as the control group,and 50 cases of healthy people who came to the hospital for physical examination were selected as the healthy control group.HLA-B27,VAS score and ESR were detected in the two groups respectively,and the observation group was divided into two groups according to VAS score,and the differences of each indicator were analyzed.Results There were significant differences in the positive rate of HLA-B27,VAS scores and ESR among the three groups(P<0.05),among which the highest level was in the observation group,the second was in the control group,and the lowest was in the health control group;the VAS score in the observation group was significantly higher than that in the HLA-B27 negative group(P<0.05);there was no significant correlation between the positive rate of HLA-B27 in the control group and the distribution of VAS grades(P>0.05).Compared with the observation group,the difference of VAS grading distribution was statistically significant(P<0.05);the difference of Kellgren Lawrence grading distribution of HLA-B27 positive and negative patients in the observation group was statistically significant(P<0.05);the difference of Kellgren Lawrence grading between HLA-B27 positive and negative patients in the control group was not statistically significant(P>0.05),but there was significant difference in distribution between the two groups(P<0.05).Conclusion The positive expression of HLA-B27 in patients with colitis and arthropathy is abnormal,which is related to the joint involvement to a certain extent,that is,when the VAS score of patients are with higher positive expression,the joint pain is more obvious.

关 键 词：结直肠炎 关节病 HLA-B27 VAS评分 

分 类 号：R446.6[医药卫生—诊断学]