一种含吲哚基希夫碱的合成及其抗菌活性研究  

Synthesis and antibacterial activity of an indolyl Schiff base

作　　者：余露[1] 赵迎春[1] 周芸 吕文韬 夏静 谷晓霞[1] YU Lu;ZHAO Yingchun;ZHOU Yun;Lü Wentao;XIA Jing;GU Xiaoxia(Department of Chemistry,School of Pharmacy,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院化学教研室

出　　处：《皖南医学院学报》2019年第6期524-527,共4页Journal of Wannan Medical College

基　　金：国家自然科学基金项目(21602157);安徽省大学生创新训练项目(201710368168);皖南医学院博士启动基金(rcqd201612)

摘　　要：目的:研究对(N,N-二甲氨基)苯甲醛缩色胺希夫碱的制备方法及抗菌活性。方法:通过色胺与对(N,N-二甲氨基)苯甲醛反应合成出一种新型含吲哚基希夫碱,该希夫碱经过核磁共振、红外、紫外光谱等表征。采用滤纸片法测定该希夫碱对大肠杆菌、金黄色葡萄球菌和白色念株菌的抗菌活性。结果:该希夫碱对大肠杆菌、金黄色葡萄球菌都有抑制作用,且抑制活性与浓度呈现一定的依赖性;当含吲哚基希夫碱的浓度达到0.20 mol/L时,对大肠杆菌的抑菌圈直径达到18 mm,对金黄色葡萄球菌的抑菌圈直径达到14 mm,对白色念珠菌的抑菌圈直径仅达到7 mm。结论:通过色胺与对(N,N-二甲氨基)苯甲醛反应制得含吲哚基希夫碱,该希夫碱的抗菌活性对大肠杆菌达到高度敏感,对金黄色葡萄球菌具有中度敏感,而对白色念珠菌低度敏感,为进一步研究吲哚类希夫碱的生物活性提供参考依据。Objective:To investigate the preparation technique and antibacterial activity of p-(N,N-dimethylamino)benzaldehyde condensating tryptamine Schiff base.Methods:The novel indolyl Schiff base was synthesized by condensation reaction of tryptamine with p-N,N-dimethylaminobenzaldehyde,and characterized by infrared absorption spectroscopy(IR),ultravioletray(UV),and nuclear magnetic resonance(NMR)spectra.Filter paper method was used to determine the antibacterial activity of the indolyl Schiff base against Escherichia coli(E.coli),Staphylococcus aureus and Candida albicans.Results:The Schiff base was able to inhibit E.coli),Staphylococcus aureus,and the inhibition activity presented concentration dependence to some extent.The diameter of the inhibition zone for E.coli,Staphylococcus aureus and Candida albicans arrived at 18,14 and 7 mm,respectively,upon indolyl Schiff base concentration being 0.20 mol/L.Conclusion:The indolyl Schiff base was prepared by reaction of tryptamine with p-N,N-dimethylamino benzaldehyde.The inhibition activity of Schiff base shows high sensitivity to E.coli,moderate to Staphylococcus aureus,yet low to Candida albicans.Our findings may be the foundation for further study on the biological activity of indolyl Schiff bases.

关 键 词：吲哚 希夫碱 合成 抗菌活性 

分 类 号：R962[医药卫生—药理学] R914[医药卫生—药学]