支气管哮喘患儿血清中E选择素、可溶性细胞黏附分子-1和白细胞介素-25、-33的变化及其意义  

Changes of Serum sE-SLT,sICAM-1,IL-25 and IL-33 and Their significance in Children with Bronchial Asthma

作　　者：李会娟[1] 梁东阁 常会娟 靳秀红[1] Li Huijuan;Liang Dongge;Chang Huijuan;Jin Xiuhong(Department of Respiratory Medicine,Children's Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院呼吸科

出　　处：《成都医学院学报》2019年第6期778-781,共4页Journal of Chengdu Medical College

摘　　要：目的探讨支气管哮喘患儿血清中可溶性细胞间黏附分子-1(sICAM-1)、E选择素(sE-SLT)、白细胞介素-25(IL-25)、白细胞介素-33(IL-33)的变化与其病情的关系。方法选取2015年11月至2018年6月在郑州大学附属儿童医院确诊的支气管哮喘急性发作期患儿作为急性期组(n=90)、哮喘缓解期患儿为缓解期组(n=60),同期健康体检儿童作为对照组(n=60)。检测3组的血清sE-SLT、sICAM-1、IL-25及IL-33、第1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)、用力肺活量(FVC)并进行比较。结果急性期组的血清sE-SLT、sICAM-1、IL-25及IL-33明显高于缓解期组和对照组(P<0.05);缓解期组的血清sE-SLT、sICAM-1、IL-25及IL-33明显高于对照组(P<0.05);急性期组的FEV1、PEF、FVC明显低于缓解期组和对照组(P<0.05);缓解期组的FEV1、PEF、FVC与对照组比较,差异无统计学意义(P>0.05);重度组的血清sE-SLT、sICAM-1、IL-25及IL-33水平高于轻度组和中度组(P<0.05);中度组的血清sE-SLT、sICAM-1、IL-25及IL-33水平高于轻度组(P<0.05);支气管哮喘急性期组患儿血清sE-SLT、sICAM-1、IL-25及IL-33水平与FEV1、PEF测定值均呈负相关(P<0.05)。结论血清sE-SLT、sICAM-1、IL-25及IL-33水平升高与支气管哮喘患儿病情发作及其严重程度有关。Objective To investigate the changes of serum soluble intercellular adhesion molecule-1(sICAM-1),soluble E-selectin(sE-SLT),interleukin-25(IL-25)and interleukin-33(IL-33)and their relationship with the condition in children with bronchial asthma.Methods A total of 150 children with bronchial asthma diagnosed in Children’s Hospital Affiliated to Zhengzhou University from November of 2015 to June of 2018 were selected and divided into the acute phase group of 90 cases with acute bronchial asthma and the remission phase group of 60 cases with asthma remission.The other 60 healthy children undergoing the physical examination over the corresponding period were selected into the control group.The levels of serum sE-SLT,sICAM-1,IL-25 and IL-33 and those of the first second forced expiratory volume(FEV1%),peak expiratory flow(PEF)and forced vital capacity(FVC)in the three groups were detected and compared.Results The levels of serum sE-SLT,sICAM-1,IL-25 and IL-33 in the acute phase group were significantly higher than those in the remission phase group and the control group respectively(P<0.05),and those in the remission phase group were significantly higher than those in the control group(P<0.05).The levels of FEV1%,PEF and FVC in the acute phase group were significantly lower than those in the remission phase group and the control group respectively(P<0.05),while there were no significant differences in the levels of FEV1%,PEF and FVC between the remission phase group and the control group(P>0.05).The levels of serum sE-SLT,sICAM-1,IL-25 and IL-33 in the severe group were significantly higher than those in the mild and moderate groups respectively(P<0.05),and those in the moderate group were significantly higher than those in the mild group(P<0.05).The levels of serum sE-SLT,sICAM-1,IL-25 and IL-33 were negatively correlated with the levels of FEV1%and PEF in the acute phase group(P<0.05).Conclusion The elevated levels of serum sE-SLT,sICAM-1,IL-25 and IL-33 are correlated with the onset and severity of bronchial ast

关 键 词：支气管哮喘 可溶性细胞间黏附分子-1 E选择素 白细胞介素-25 白细胞介素-33 

分 类 号：R725.6[医药卫生—儿科]