不同剂量阿托伐他汀联合法舒地尔治疗冠状动脉慢血流的效果对比  

Effect of different doses of atorvastatin combined with fasudil on coronary slow flow:a comparative study

作　　者：李立卓[1] 郑梅[2] 李卓伟[3] 彭文华[4] 赵清珍[1] 甄宇治[1] LI Li-zhuo;ZHENG Mei;LI Zhuo-wei;PENG Wen-hua;ZHAO Qing-zhen;ZHEN Yu-zhi(the First Department of Cardiology,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China;the Third Department of Cardiology,the First Hospital of Shijiazhuang,Shijiazhuang 050011,China;Hebei Yuanzheng Pharmaceutical CO.,LTD,Shijiazhuang 050000,China;Department of Cardiology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]河北医科大学第一医院心内一科,石家庄市050031 [2]河北省石家庄市第一医院心内三科,石家庄市050011 [3]河北远征药业有限公司,石家庄市050000 [4]中日友好医院心内科,北京市100029

出　　处：《广西医学》2019年第21期2688-2691,共4页Guangxi Medical Journal

基　　金：河北省医学科学研究重点课题(20170482)

摘　　要：目的对比不同剂量阿托伐他汀联合法舒地尔治疗冠状动脉慢血流(CSF)的效果。方法将102例CSF患者随机分为对照组、常规组和强化组,每组34例。3组患者均给予阿司匹林治疗,在此基础上常规组给予阿托伐他汀20 mg/d和法舒地尔60 mg/d治疗,强化组给予阿托伐他汀40 mg/d和法舒地尔60 mg/d治疗。观察治疗后2周3组患者治疗总有效率,比较治疗前后3组患者高敏C反应蛋白(hs-CRP)、血清肿瘤坏死因子α(TNF-α)、白细胞介素1(IL-1)、一氧化氮水平。结果治疗后,强化组、常规组总有效率均高于对照组(均P<0.05),但常规组与强化组总有效率差异无统计学意义(P>0.05);强化组及常规组hs-CRP、TNF-α、IL-1水平均较治疗前及对照组降低,一氧化氮水平较治疗前及对照组升高(均P<0.05)。结论在常规治疗基础上,联用法舒地尔和阿托伐他汀,可有效地改善CSF患者炎症反应,提高治疗效果,但常规剂量和强化剂量阿托伐他汀效果相当。Objective To compare the effect of different doses of atorvastatin combined with fasudil on coronary slow flow(CSF).Methods A total of 102 patients with CSF were randomly divided into control group,routine group and intensive group,with 34 cases in each group.The patients in the three groups were all administered aspirin.On this basis,the routine group was administered atorvastatin(20 mg/d) and fasudil(60 mg/d),while the intensive group received atorvastatin(40 mg/d) and fasudil(60 mg/d).The total therapeutic effective rate at 2 weeks after treatment was observed in the three groups,and the levels of high-sensitivity C-reactive protein(hs-CRP),serum tumor necrosis factorα(TNF-α),interleukin 1(IL-1) and nitric oxide(NO) before and after treatment were compared between the three groups.Results After treatment,the total effective rates of the intensive group and routine group were higher than that of the control group(all P<0.05),but there was no statistically significant difference in the total effective rate between the routine group and intensive group(P>0.05);the intensive group or routine group had lower levels of hs-CRP,TNF-α and IL-1,as well as a higher NO level as compared with pre-therapy and the control group(all P<0.05).Conclusion On the basis of conventional therapy,atorvastatin combined with fasudil can effectively alliviate inflammatory response in the CSF patients,improve curative effect,however the efficacy of routine dose and intensive dose of atorvastatin is equivalent.

关 键 词：冠状动脉慢血流 阿托伐他汀 法舒地尔 不同剂量 

分 类 号：R543.3[医药卫生—心血管疾病]