冠状动脉微血管疾病研究进展  

Progress in Coronary Microvascular Disease

作　　者：夏钰琪 步睿[1] 王晓云[1] XIA Yu-qi;BU Rui;WANG Xiao-yun(Department of Cardiology,Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院心内科

出　　处：《微循环学杂志》2019年第4期69-73,共5页Chinese Journal of Microcirculation

基　　金：国家自然科学基金(61572152)

摘　　要：冠状动脉微血管疾病(CMVD)是指冠状动脉前小动脉和小动脉的结构和(或)功能在各种致病因素作用下发生异常,导致劳力性心绞痛或客观性心肌缺血的临床综合征。CMVD的发病机制尚未完全明确,但是内皮功能障碍、炎症反应和异常伤害感受都可能是其发病机制。CMVD的患病率逐年升高,且女性多于男性,尤其多见于绝经后女性,提示了雌激素缺乏可能为CMVD的潜在致病因素,也将性别视为导致微血管功能障碍的重要影响因素。因此,雌激素替代治疗可能成为CMVD治疗的新靶点。Coronary microvascular disease refers to a clinical syndrome in which the structure and/or function of the anterior small arteries and arterioles of the coronary arteries are abnormal under various pathogenic factors,leading to exertional angina or objective myocardial ischemia.Although the pathogenesis of coronary microvascular disease is not completely understood,endothelial dysfunction,inflammatory reaction,abnormal nociception may be the pathogenesis.The morbidity of coronary microvascular disease is increasing year by year,in which female patients is more than males,especially postmenopausal women.It suggests that estrogen deficiency may be a potential pathogenic factor of coronary microvascular disease.Gender is also considered to be an important factor which influences microvascular function.Therefore,estrogen replacement therapy may become a new therapeutic target for coronary microvascular disease.

关 键 词：冠状动脉微血管疾病 雌激素 心脏磁共振成像 

分 类 号：R543.3[医药卫生—心血管疾病]