心脉隆注射液对ADP和花生四烯酸诱导血小板聚集的影响  

Influence of Xinmailong Injection on ADP and Arachidonic Acid-induced Platelet Aggregation

作　　者：韩亚娟 杨泽康 王梦蝶 沈磊 HAN Yajuan;YANG Zekang;WANG Mengdie;SHEN Lei(College of Pharmacy and Chemistry,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali 671000,China)

机构地区：[1]大理大学药学与化学学院,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000

出　　处：《中国民族民间医药》2019年第21期12-15,31,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学基金项目(81560634);云南省昆虫生物医药研发重点实验室开放课题项目(2016-18)

摘　　要：目的:观察心脉隆注射液(XML)对血小板聚集的影响。方法:使用血小板聚集仪观察不同浓度的XML对二磷酸腺苷(ADP)和花生四烯酸(AA)诱导血小板聚集的影响,及是否诱导正常血小板聚集。结果:1 g/L的XML能显著抑制ADP诱导的血小板聚集,抑制率为7.8%;1 g/L和0.5 g/L的XML也明显抑制AA诱导的血小板聚集,抑制率分别为57.7%和20.5%;所有浓度的XML均不能直接诱导血小板聚集。结论:XML能剂量依赖性地抑制不同诱导剂引起的血小板聚集,且对ADP诱导血小板聚集的抑制作用强于AA。Objective To observe the influence of XML on platelet aggregation.Methods The influences of different concentration of XML on ADP and Arachidonic Acid(AA)-induced platelet aggregation,or on normal function of platelet were evaluated by platelet aggregation analyzer.Results 1 g/L XML significantly inhibited ADP-induced platelet aggregation with 7.8%inhibition rate;1g/L and 0.5g/LXML obviously inhibited AA-induced platelet aggregation with 57.7%and 20.5%inhibition rate,respectively.All concentrations of XML could not induce platelet aggregation.Conclusion XML dose-dependently inhibited platelet aggregation induced by different inducers,and the inhibitory effect of XML on platelet aggregation induced by ADP was stronger than that induced by AA.

关 键 词：心脉隆注射液 血小板聚集 二磷酸腺苷 花生四烯酸 

分 类 号：R285.5[医药卫生—中药学]