血小板微粒与急性冠脉综合征危险分层及临床预后的关系  

Relationship between platelet microparticles and risk degree of acute coronary syndrome patients, clinical prognosis

作　　者：马牧欣 符国平[1] 朱勇德[1] 王真奎 赵继义 MA Mu-xin;FU Guo-ping;ZHU Yong-de;WANG Zhen-kui;ZHAO Ji-yi(The Third People s Hospital of Hainan Province,Sanya 527000,China)

机构地区：[1]海南省第三人民医院,海南57200 [2]哈尔滨医科大学附属第一医院

出　　处：《内科急危重症杂志》2019年第5期391-393,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:评价循环血小板微粒(PMPs)与急性冠脉综合征(ACS)危险分层及临床预后的关系。方法:选取53例ACS患者为ACS组,招募同期就诊的稳定性心绞痛(SA)及体检的非冠心病(CAD)患者共53例为对照组。所有受试者入院即刻检测循环PMPs水平,同时随访ACS患者出院后1个月内发生主要不良心血管事件(MACE)情况。分析PMPs在各组及亚组间差异性。结果:①PMPs水平在急性心肌梗死(AMI)亚组(12.78%±3.61%)最高,不稳定性心绞痛(UA)亚组(8.64%±5.29%)PMPs水平显著高于SA(4.27%±2.45%)及非CAD亚组(3.55%±1.81%);②高危亚组患者PMPs水平显著高于中危及低危亚组(P<0.05);③发生MACE的ACS患者入院时PMPs水平显著高于非MACE患者(13.53%±3.54%vs 7.57%±1.69%,P<0.05)。结论:PMPs是潜在的评估ACS疾病病情与近期临床预后的标记物。Objective: To evaluate the relationship between platelet microparticles(PMPs) and risk degree of acute coronary syndrome(ACS) patients, clinical prognosis. Methods: All of 53 patients with ACS served as ACS group, and 53 patients without coronary artery disease(CAD) and stable angina(SA) served as control group. The levels of PMPs were detected on admission and major adverse cardiovascular events(MACE) were observed during the follow-up period of 30 days after discharge. Results: It was found that: ①Levels of PMPs were highest in AMI subgroup(12.78%±3.61%), and PMPs levels in UA subgroup(8.64%±5.29%) were significantly higher than in SA subgroup(4.27%±2.45%) and non-CAD subgroup(3.55%±1.81%);②The levels of PMPs were significantly higher in high risk subgroup than others;③The levels of PMPs were significantly higher in patients with MACE than in those without MACE(13.53%±3.54% vs 7.57%±1.69%, P<0.05). Conclusions: PMPs served as a potential marker for assessing the risk degree of ACS and clinical prognosis.

关 键 词：血小板微粒 急性冠脉综合征 危险分层 预后 

分 类 号：R541.4[医药卫生—心血管疾病]