补肾活血方对创伤骨折患者术后血清PCT与CRP的影响及疗效  

Effect of Bushen Huoxue Recipe on Serum PCT and CRP in Patients with Traumatic Fracture

作　　者：郭晓征 王胜利 丁尔勤[2] GUO Xiaozheng;WANG Sheng-li;DING Er-qin(Department of Surgery,Zhongxin Eco-city Hospital,Tianjin Medical University,Tianjin(300467),China)

机构地区：[1]天津医科大学中新生态城医院外科(骨外),天津300467 [2]天津港口医院骨科,天津300456

出　　处：《中国中西医结合外科杂志》2019年第6期977-981,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:观察补肾活血方对胫骨创伤开放性骨折患者术后血清中降钙素原(PCT)与C-反应蛋白(CRP)的影响及疗效。方法:对2015年4月—2019年5月作者经手治疗的因创伤而发生骨折且行手术治疗的96例患者进行回顾性分析,按照随机表法分成常规组(48例)与观察组(48例),常规组予以抗感染、止痛及纠正电解质紊乱等一系列对症支持疗法,观察组则是在常规组之上加用中药补肾活血方,对比两组术后1天、2周与12周血清PCT、CRP含量、Kofoed踝关节与Lysholm膝关节(LKSS)评分、视觉模拟疼痛(VAS)评分及临床疗效。结果:在术后1天,两组患者血清PCT与CRP含量、Kofoed与LKSS评分及VAS评分无统计差异(P>0.05);在术后2周、12周,常规组血清PCT与CRP含量、VAS评分均高于观察组,而Kofoed与LKSS评分低于观察组,存在统计学差异(P<0.05);与术后1天相比,两组患者术后2周、12周血清PCT与CRP含量、Kofoed与LKSS评分及VAS评分均明显改善,有统计学差异(P<0.05);常规组与观察组的临床总有效率分别为75.00%(36/48)、93.75%(45/48),有统计学差异(P<0.05)。结论:补肾活血方能够减轻胫骨创伤开放性骨折患者术后所发生的炎性反应,改善患者踝膝关节的功能,减轻患者疼痛感,促使骨折愈合,且临床疗效尚可。Objective To observe the effect and efficacy of serum procalcitonin(PCT)and C-reactive protein(CRP)in patients with open wounds.Methods A retrospective analysis of 96 patients undergoing trauma and fractured surgery from April 2015 to May 2019 was performed.The patients were divided into the conventional group(48 cases)and the observation group(48 cases)according to the randomized table.The patients in conventional group received a series of symptomatic supportive therapies for anti-infection,analgesia and correction of electrolyte imbalance.The patients in observation group were treated with traditional Chinese medicine Bushen Huoxue Recipe based on the regular group.The serum levels of PCT and CRP,Kofoed ankle and Lysholm knee(LKSS)scores,visual analogue pain(VAS)scores,and clinical outcomes of two groups were compared for 1 day,2 weeks and 12 weeks.Results There was no statistical difference in serum PCT and CRP,Kofoed and LKSS scores,and VAS scores between the two groups for 1 day after surgery(P>0.05).At 2 and 12 weeks after surgery,serum PCT and CRP levels and the VAS scores in the routine group were higher than the observation group,while the Kofoed and LKSS scores were lower than those in the observation group,with statistical difference(P<0.05).Two groups of serum PCT and CRP,Kofoed and LKSS scores and VAS scores were significantly improved at 2 weeks and 12 weeks after surgery(P<0.05).The total clinical effective rates of the conventional group and the observation group were 75.00%(36/48)and 93.75%(45/48),respectively.There was a statistical difference(P<0.05).Conclusion Bushen Huoxue Recipe can alleviate the inflammatory reaction after operation in patients with open fractures of the tibia,improve the function of the knee joint, relieve the pain and promote the fracture healing, and the clinical effect is acceptable.

关 键 词：创伤骨折 降钙素原 补肾活血方 C-反应蛋白 疗效 

分 类 号：R285.6[医药卫生—中药学] R683[医药卫生—中医学]