参菖益智胶囊的质量研究  

Study on Quality Standard of Shenchang Yizhi Capsules

作　　者：张德珂[1] 李季 李玥[1] 曲远均[1] ZHANG De-ke;Li Ji;Li Yue;QU Yuan-jun(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院

出　　处：《食品与药品》2019年第6期430-434,共5页Food and Drug

基　　金：山东省中医药科技发展计划项目（编号（2015-092）

摘　　要：目的建立参菖益智胶囊的质量控制方法。方法采用薄层色谱法(TLC)对参菖益智胶囊中的人参、石菖蒲进行定性鉴别;采用高效液相色谱法(HPLC)对人参中人参皂苷Rg1、人参皂苷Re和人参皂苷Rb1进行含量测定。结果薄层色谱清晰,分离良好,阴性无干扰;人参皂苷Rg1、人参皂苷Re和人参皂苷Rb1线性关系良好,平均加样回收率分别为100.48%,102.10%,101.44%,RSD为1.79%,1.76%,1.55%。结论该方法简便易行、灵敏准确、专属性强,可用于参菖益智胶囊的质量控制。Objective To establish some methods for the quality control of Shenchang Yizhi Capsules.Methods Thin layer chromatography(TLC)was used for the identification of Ginseng radix et rhizoma and Acori tatarinowii rhizoma in Shenchang Yizhi Capsules and HPLC was adopted in the content determination of ginsenoside Rg1,ginsenoside Re and ginsenoside Rb1.Results The clear and well-separated TLC spots were free from negative interference.Peak area of ginsenoside Rg1,ginsenoside Re and ginsenoside Rb1 showed good linear relationship with amount of sample,with the average recoveries of 100.48%(RSD=1.79%),102.10%(RSD=1.76%)and 101.44%(RSD=1.55%),respectively.Conclusion This simple,reliable and accurate method can be used for the quality control of Shenchang Yizhi Capsules.

关 键 词：参菖益智胶囊 人参皂苷RG1 人参皂苷RE 人参皂苷RB1 质量控制 

分 类 号：R927.11[医药卫生—药学]