重症肌无力合并感染的抗菌药应用进展  

Antibiotic Application of Myasthenia Gravis Complicated with Infection

作　　者：潘纬榕 沈娴 孙思娴 朱旭莹[1] PAN Weirong;SHEN Xian;SUN Sixian;ZHU Xuying(Department of Neurology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

机构地区：[1]上海中医药大学附属曙光医院神经内科

出　　处：《中国药物警戒》2019年第10期625-631,共7页Chinese Journal of Pharmacovigilance

基　　金：上海市中医临床优势专科建设项目（ZYSNXDYL-YSZK004）

摘　　要：重症肌无力(myasthenia gravis, MG)是一种主要累及神经肌肉接头突触后膜乙酰胆碱受体的获得性自身免疫疾病。感染是MG病情发展过程中最常见的并发症之一,然而部分抗菌药干扰神经-肌肉接头运动,可能导致MG症状加重,甚至诱发肌无力危象。因此合理选择抗菌药,对MG患者尤为重要。本文对影响MG症状的抗菌药进行了归纳总结,并对抗菌药的选择提出了推荐意见,以期对临床医师运用抗菌药及新型药物研发提供参考信息。Myasthenia gravis( MG) is an acquired autoimmune disease that primarily affects the postsynaptic membrane acetylcholine receptors of neuromuscular junctions. Infection is one of the most common complications in the development of MG. However, some antibacterial drugs interfere with the movement of nerve-muscle joints, which may aggravate the symptoms of MG and even induce myasthenic crisis. Therefore, cautious selection of antibacterial drugs is particularly important for MG patients. This paper summarizes the antibacterial drugs that affect the symptoms of MG, and raise recommendations for the selection of antibacterial drugs in order to provide reference for clinicians to use antibacterial drugs and for new drug research and development.

关 键 词：重症肌无力 感染 神经肌肉阻滞 抗菌药 

分 类 号：R978.1[医药卫生—药品]