早期肠内营养对重症患者院内感染及多重耐药菌感染的临床研究  

Clinical study of early enteral nutrition on nosocomial infection and mul-ti-drug resistant infection in critically ill patients

作　　者：余栋栽[1] 林熙泉[1] 谭家香[1] 张旺龙[1] 温嘉强[1] 吴彬[1] 梁丹青 YU Dong-zai;LIN Xi-quan;TAN Jia-xiang;ZHANG Wang-long;WEN Jia-qiang;WU Bin;LIANG Dan-qing(Department of Critical Care Medicine,Kaiping Central Hospital,Guangdong Province,Kaiping 529300,China)

机构地区：[1]广东省开平市中心医院重症医学科

出　　处：《中国当代医药》2019年第33期45-47,共3页China Modern Medicine

基　　金：广东省江门市第十批医疗卫生科技计划项目(江科[2017]159号)

摘　　要：目的探讨早期肠内营养对重症患者院内感染及多重耐药菌感染的临床效果。方法选取2017年4月~2018年12月在我院住院治疗的200例危重症患者作为研究对象,根据随机数字表法将其分为对照组和治疗组,每组各100例。对照组患者采用早期肠外营养治疗及延迟肠内营养,治疗组患者采用早期肠内营养治疗。比较两组患者的治疗总有效率;比较两组患者的ICU住院时间;比较两组患者治疗前后的降钙素原、C反应蛋白、CD4+淋巴细胞/CD8+淋巴细胞比值;比较两组患者的血常规、肝肾功能。结果治疗组患者的治疗总有效率高于对照组,ICU住院时间短于对照组,治疗后的降钙素原、C反应蛋白水平低于对照组,CD4+淋巴细胞/CD8+淋巴细胞比值高于对照组,差异有统计学意义(P<0.05)。治疗组患者的院内感染发生率、多重耐药菌感染发生率低于对照组,差异有统计学意义(P<0.05)。结论早期肠内营养对重症患者院内感染及多重耐药菌感染的临床预防效果确切,值得应用推广。Objective To investigate the clinical effect of early enteral nutrition on nosocomial infection and multi-drug resistant infection in critically ill patients.Methods A total of 200 critically ill patients admitted into our hospital from April 2017 to December 2018 were selected as subjects.They were divided into control group and treatment group according to the random number table method,with 100 cases in each group.In the control group,early parenteral nutrition and delayed enteral nutrition were used,while in the treatment group,early enteral nutrition was adopted.The total effectiveness rate of the two groups was compared between the two groups.The duration of intensive care unit(ICU)stay,the levels of procalcitonin and C-reactive protein,and the ratio of lymphocytes CD4+to CD8+before and after treatment were compared between the two groups.The blood routine,liver and kidney function were also compared between the two groups.Results The total effectiveness rate in the treatment group was higher than that of the control group,the ICU stay was shorter than that of the control group,the levels of the procalcitonin and C-reactive protein after treament were lower than those of the control group,the ratio of CD4+to CD8+in lymphocytes was higher than that of the control group,the differences were statistically significant(P<0.05).The incidence of nosocomial infection and multi-drug resistant infection in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Early enteral nutrition is effective in the prevention of nosocomial infections and multi-drug resistant infections in critically ill patients,is worthy of application and promotion.

关 键 词：早期肠内营养 重症患者 院内感染 多重耐药菌感染 临床研究 

分 类 号：R473.5[医药卫生—护理学]