我院208例药品不良反应报告分析  

Analysis of adverse drug reactions in our hospital in 208 cases

作　　者：马冰洁 李昌容 苍爱军[1] MA Bing-jie;LI Chang-rong;CANG Ai-jun(Department of Pharmacy,Liaoning Provincial People′s Hospital,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院药学部

出　　处：《中国当代医药》2019年第33期139-142,共4页China Modern Medicine

摘　　要：目的研究辽宁省人民医院(以下简称“我院”)发生的208例药品不良反应(ADR)的发生特点,为提高ADR的监测水平和指导临床合理用药提供参考。方法选取某院2017年1月~2018年12月上报国家ADR监测网的208例ADR报告作为研究对象进行回顾性分析,从患者的性别、年龄、ADR类型、给药途径、药品种类分布、累及器官或系统、报告人职业和ADR关联性评价等方面,进行回顾性统计与分析。结果我院ADR报告中,≥45岁的患者较多,共179例;女性略低于男性;ADR涉及药品14类,其中造影剂居首位;ADR累及器官或系统共11类,以皮肤及其附件损害最多见;ADR报告人职业以医师和药师为主。ADR关联性判定结果分别为肯定、很可能、可能,其中很可能所占比例最大。结论我院的ADR有其自身特点,应重点关注ADR易发的药物和人群,选择合适的给药途径,临床工作中需重视ADR的监测,不断提高临床合理用药水平,以避免或减少ADR的重复发生。Objective To study the characteristics of 208 adverse drug reactions(ADR)occurring in Liaoning Provincial People′s Hospital(hereinafter referred to as"our hospital"),and provide reference for improving ADR monitoring level and clinical rational drug use.Methods A total of 208 ADR reports were submitted to the National ADR Monitoring Network from January 2017 to December 2018 were selected as the research objects for retrospective analysis.The data including gender,age,ADR type,route of administration,distribution of drug types,involved organs or systems,and occupation of reporters,and evaluation on ADR correlation were retrospectively analyzed.Results In ADR reports of our hospital,there were more patients≥45 years old,totaling 179 cases.Women were slightly lower than men.ADR involveed 14 kinds of drugs,of which contrast agents were the first.ADR involveed 11 types of organs or systems,with skin and its accessories were the most common.ADR reporters were mainly physicians and pharmacists.The ADR correlation judgments were classified as affirmation,probability,and possibility,of which probability took the highest proportion.Conclusion ADR in our hospital has its own characteristics.It should focus on the drugs and patient groups that are prone to ADR,choose the appropriate route of administration,pay attention to the monitoring of ADR in clinical practice,and continuously improve the level of rational drug use to avoid or reduce the recurrence of ADR.

关 键 词：药品不良反应 监测 合理用药 回顾性分析 

分 类 号：R927.1[医药卫生—药学]