血清和支气管肺灌洗液中多项指标对重症肺炎的诊断价值  

Diagnostic value of indexes in serum and bronchopulmonary lavage fluid for severe pneumonia

作　　者：陈咏芳[1] 唐玮欣 陈丽芳[2] CHEN Yong-fang;TANG Wei-xin;CHEN Li-fang(Department of Clinical Laboratory,Longgang Central Hospital of Shenzhen City,Guangdong Province,Shenzhen 518172,China;Department of Clinical Laboratory,Shenzhen Longgang District People′s Hospital,Guangdong Province,Shenzhen 518172,China)

机构地区：[1]深圳市龙岗中心医院检验科,广东深圳518172 [2]深圳市龙岗区人民医院检验科,广东深圳518172

出　　处：《中国当代医药》2019年第33期165-168,F0004,共5页China Modern Medicine

摘　　要：目的探讨血清和支气管肺灌洗液对重症肺炎的诊断价值。方法选取2016年7月深圳市龙岗区人民医院收治的21例诊断为重症肺炎患者为重症肺炎组,同期选取13例未达到重症肺炎诊断标准的患者为对照组,检测两组患者血清和支气管肺灌洗液的中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、白细胞(WBC)、C反应蛋白(CRP)和降钙素原(PCT)的含量,并进行比较分析。结果重症肺炎组血清和支气管肺灌洗液的NGAL含量多于对照组,差异有统计学意义(P<0.05)。根据ROC曲线可知:血清和支气管肺灌洗液中多个指标,只有NGAL对重症肺炎诊断有意义(P<0.05)。血清NGAL对重症肺炎诊断的特异度为69.2%,灵敏度为69.2%;支气管肺灌洗液对重症肺炎诊断的特异度为71.4%,灵敏度为81.0%。结论在血清和支气管肺灌洗液中,与WBC,CRP和PCT比较,NGAL对重症肺炎的诊断价值较高,临床应用价值较高。Objective To investigate the diagnostic value of indexes in serum and bronchopulmonary lavage fluid for severe pneumonia.Methods A total of 21 patients diagnosed with severe pneumonia admitted to Shenzhen Longgang District People′s Hospital in July 2016 were selected as the severe pneumonia group,while 13 patients who did not meet the diagnostic criteria for severe pneumonia were selected as the control group.The contents of neutrophil gelatinase-related lipocalin(NGAL),white blood cells(WBC),C-reactive protein(CRP)and procalcitonin(PCT)in serum and bronchopulmonary lavage fluid of the two groups were detected and compared.Results The NGAL content in serum and bronchopulmonary lavage fluid of severe pneumonia group were higher than those of the control group,with statistical significance(P<0.05).According to the ROC curve drawn,only NGAL had significance in the diagnosis of severe pneumonia among indexes in serum and bronchopulmonary lavage fluid(P<0.05).The specificity and sensitivity of serum NGAL in the diagnosis of severe pneumonia were 69.2%and 69.2%,respectively.The specificity and sensitivity of bronchopulmonary lavage fluid in the diagnosis of severe pneumonia were 71.4%and 81.0%,respectively.Conclusion Compared with WBC,CRP and PCT in serum and bronchopulmonary lavage fluid,NGAL has higher diagnostic value and higher clinical application value for severe pneumonia.

关 键 词：重症肺炎 血清 支气管肺灌洗液 中性粒细胞明胶酶相关脂质运载蛋白 白细胞 C反应蛋白 降钙素原 

分 类 号：R563.1[医药卫生—呼吸系统]