丙基硫氧嘧啶对妊娠合并甲状腺功能亢进孕妇甲状腺功能及妊娠结局的影响  

Effect of Propylthiouracil on Thyroid Function and Pregnancy Outcome in Pregnant Women with Hyperthyroidism

作　　者：章莉荔 ZHANG Lili(Jianyang District Maternal and Child Health Hospital of Nanping City,Nanping 354200,China)

机构地区：[1]南平市建阳区妇幼保健院

出　　处：《中外医学研究》2019年第32期141-142,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨妊娠合并甲状腺功能亢进孕妇实施丙基硫氧嘧啶治疗对甲状腺功能及妊娠结局的影响。方法:选取2017年1月-2018年8月妇产科60例妊娠合并甲状腺功能亢进孕妇,根据用药状况分为常规组(n=30,采用甲巯咪唑治疗)和干预组(n=30,采用丙基硫氧嘧啶治疗),分析两组用药效果。结果:治疗2个月后,干预组FT4、FT3水平,以及剖宫产、早产、妊娠期高血压疾病、胎儿宫内窘迫、低体重儿发生率均低于常规组,TSH水平高于常规组,差异均有统计学意义(P<0.05)。结论:对妊娠合并甲状腺功能亢进孕妇实施丙基硫氧嘧啶治疗可改善甲状腺功能及妊娠结局。Objective:To investigate the effect of Propylthiouracil on thyroid function and pregnancy outcome in pregnant women with hyperthyroidism.Method:Sixty pregnant women with hyperthyroidism in the department of obstetrics and gynecology from January 2017 to August 2018 were selected.According to pregnant women medication status,they were divided into the routine group(n=30,treated with Methimazole)and the intervention group(n=30,treated with Propylthiouracil),and effects of two groups were analyzed.Result:After 2 months of treatment,the levels of FT4,FT3 and the incidence of cesarean section,premature delivery,gestational hypertension disease,fetal distress and low birth weight infants in the intervention group were lower than those of the routine group,and the differences were statistically significant(P<0.05).Conclusion:Treatment with Propylthiouracil in pregnant women with hyperthyroidism can improve thyroid function and pregnancy outcome.

关 键 词：妊娠 甲状腺功能亢进 丙基硫氧嘧啶 甲状腺功能 妊娠结局 

分 类 号：R71[医药卫生—妇产科学]