超声脐动脉S/D联合血清IGF-1和胆汁酸对新生儿窒息的临床诊断价值分析  

Clinical Diagnostic Value of Ultrasound Umbilical Artery S/D Combined with Serum IGF-1 and Bile Acid in Neonatal Asphyxia

作　　者：董亚男[1] 庞远[1] 李海朋[1] 舒展[1] 肖秀娟[1] DONG Ya'nan;PANG Yuan;LI Haipeng;SHU Zhan;XIAO Xiujuan(Tangshan Union Medical College Hospital,Tangshan 063000,Hebei,P.R.China)

机构地区：[1]河北省唐山市协和医院

出　　处：《影像科学与光化学》2020年第1期80-86,共7页Imaging Science and Photochemistry

基　　金：河北省卫生和计划生育委员会科研基金项目（20160880）资助

摘　　要：本文通过观察新生窒息患儿和正常新生儿多普勒超声脐动脉血流S/D比值、血清胰岛素样生长因子(IGF-1)、胆汁酸(TBA)水平差异,探讨脐动脉血流S/D比值联合血清IGF-1和TBA在新生儿窒息中的诊断价值。实验结果表明,脐动脉血流S/D比值、血清IGF-1、TBA在新生儿窒息与正常新生儿、不同窒息程度患儿、伴新生儿缺血缺氧性脑病(HIE)的患儿中均有显著差异。多重线性回归结果表明脐动脉血流S/D比值、血清TBA、IGF-1与新生儿窒息评价指标Apgar评分存在密切关系。受试者工作特征曲线分析结果表明脐动脉血流S/D比值、血清IGF-1、TBA诊断新生儿窒息具有较高应用价值,且联合上述指标检测诊断价值更高。By observing the difference of S/D ratio of umbilical artery blood flow, serum insulin-like growth factor(IGF-1) and bile acid(TBA) levels between neonates with asphyxia and normal neonates, the diagnostic value of S/D ratio of umbilical artery blood flow combined with serum IGF-1 and TBA in neonatal asphyxia was discussed. The results showed that the S/D ratio of pulse blood flow, serum IGF-1 and TBA were significantly different between neonatal asphyxia and normal neonates,children with different degrees of asphyxia and neonatal ischemic-hypoxic encephalopathy(HIE).The results of multiple linear regression showed that umbilical artery blood flow S/D ratio,serum TBA,IGF-1 were closely related to the Apgar score of neonatal asphyxia evaluation index.The analysis of the receiver operating characteristic curve of the subjects showed that the S/D ratio of umbilical artery blood flow,serum IGF-1 and TBA had high application value in the diagnosis of neonatal asphyxia,and the combined detection of the above indicators had higher diagnostic value.

关 键 词：S/D IGF-1 胆汁酸 新生儿窒息 

分 类 号：R72[医药卫生—儿科]