基于PMMA材料的微通道快速加工技术  

Microchannel Rapid Processing Technology Based on PMMA Material

作　　者：郑杰 闫延鹏 王洪 陈艳 崔建国 ZHENG Jie;YAN Yan-peng;WANG Hong;CHEN Yan;CUI Jian-guo(College of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing 400054,China)

机构地区：[1]重庆理工大学药学与生物工程学院

出　　处：《塑料工业》2019年第11期44-48,共5页China Plastics Industry

基　　金：国家科技支撑计划项目(2015BAI01B14);重庆市高等教育教学改革研究一般项目(173114);重庆理工大学研究生教育优质课程项目资助(yyk2017106);重庆市技术创新与应用示范(社会民生类)一般项目(cstc2018jscx-msyb0290)

摘　　要：近年来,基于聚合物的微加工制造技术已经成为微细加工领域的研究热点,已广泛应用于制备芯片实验室和微流控芯片。以热压技术为基础,研究利用加热电阻丝制备微流控芯片微通道的快速加工技术,并最终实现了基于聚甲基丙烯酸甲酯(PMMA)材料的微通道快速加工,获得了电阻丝压印微通道的最优条件,在电流1.8 A、时间5 s、压力为44.59N条件下获得的微通道宽度变形率约为8.5%,深度变形量约为8.9%,可以在2 h左右制备完成PMMA微流控芯片。最后,利用该加工技术制作了十字型流动聚焦型微流控芯片,可稳定生成34~74 nL范围内的微液滴,实验结果显示利用本快速加工技术所获得的微通道圆润光滑、性能稳定、键合密封牢固。In recent years,polymer-based micromachining manufacturing technology had become a research hotspot in the field of microfabrication,and had been widely used in the preparation of chip labs and microfluidic chips.Based on the hot pressing technology,the rapid processing technology of microfluidic microchannels fabricated by heating resistor wires was studied,and finally the microchannel rapid processing based on polymethyl methacrylate(PMMA)materials was realized.The optimal conditions for the resistance wires imprinting microchannel were obtained.When the current is 1.8 A,time is 5 s and pressure is 44.59 N,the microchannel width deformation rate is about 8.5%,and the depth deformation is about 8.9%.The PMMA microfluidic chip can be prepared in about 2 h.Finally,the cross-flow type flow focusing microfluidic chip is fabricated by this processing technology,which could stabilize the microdroplets in the range of 34~74 nL.The experimental results show that the microchannel obtained by this rapid processing technology is smooth,the performance is stable and the bonding and sealing are firm.

关 键 词：聚甲基丙烯酸甲酯 电阻丝 微流控芯片 热压 正交试验 

分 类 号：TQ317.9[化学工程—高聚物工业]