T细胞免疫在脓毒症继发侵袭性真菌感染中作用的研究进展  

Advances in the study of T cell immunity in invasive fungal infections secondary to sepsis

作　　者：赵乙汜 余应喜[1] 林时辉 徐昉[1,2] ZHAO Yi-si;YU Ying-xi;LIN Shi-hui;XU Fang(Department of Critical Care Medicine,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Pathophysiology,The Basic Medicine of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院重症医学科,重庆400016 [2]重庆医科大学基础医学院病理生理学教研室,重庆400016

出　　处：《上海交通大学学报（医学版）》2019年第11期1325-1328,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81873928,81801894,81570069)~~

摘　　要：侵袭性真菌感染(invasive fungal infections,IFI)是一种具有很高发病率及死亡率的疾病,且多见于院内感染,特别是在脓毒症时,继发IFI的概率大大增加。脓毒症出现免疫抑制会影响T细胞免疫功能,不同的T细胞亚群对IFI各种真菌病原体都有不同的作用。此综述探讨了脓毒症继发IFI中T细胞免疫的病理生理变化、作用机制及治疗方法的研究进展,旨在对脓毒症继发IFI中T细胞的作用做一个总结,并介绍最新研究出的免疫治疗方法。Invasive fungal infections(IFI)has high morbidity and mortality.It is more common in hospital infections,and especially in sepsis,the risk of secondary IFI is increased.Immunosuppression of sepsis may affect immune function of T cells,and various T cells subsets have different effects on various fungal pathogens of IFI.The review discusses the pathophysiological processes,mechanism and therapeutic methods of T cell immunity in IFI secondary to sepsis,in order to summarize the role of T cells in IFI secondary to sepsis and introduce the new immunotherapy.

关 键 词：侵袭性真菌感染 T淋巴细胞亚群 脓毒症 免疫疗法 

分 类 号：Q78[生物学—分子生物学]