合肥市某单位体检人群25-羟维生素D水平与血脂的相关性  

Association between 25-hydroxy vitamin D and serum lipid in health check-up subjects of a unit in Hefei city

作　　者：金长清[1] 张晓雨[1] 童瑶 曾金玲 胡华青[1] JIN Changqing;ZHANG Xiaoyu;TONG Yao(Health Management Center&Physical Examination Center,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学第一附属医院健康管理中心

出　　处：《安徽医学》2019年第11期1272-1275,共4页Anhui Medical Journal

基　　金：安徽省公益性技术应用研究(项目编号:1704f0804019)

摘　　要：目的探讨合肥市某单位体检人群25-羟维生素D[25-(OH)D]水平与血脂的关系。方法选取2016年5月在安徽医科大学第一附属医院健康体检的合肥市某单位人员共810例为研究对象,测量810例研究对象血清25-(OH)D以及总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)等血脂指标。采用Pearson相关性分析和多元线性回归进行25-(OH)D与血脂各指标关系的多因素分析。结果810例研究对象25-(OH)D平均浓度为(15.81±4.87)ng/mL,其中25-(OH)D缺乏者占67.7%,严重缺乏者占13.0%。Pearson相关分析显示25-(OH)D与TC、三酰甘油对数值(lgTG)和HDL-C均呈负相关(P<0.05),多因素分析显示血清25-(OH)D与TC(β值=-0.015,95%CI=-0.029^-0.002,P=0.021)和lgTG(β值=-0.008,95%CI=-0.011^-0.005,P<0.001)呈显著负相关。结论合肥市某单位体检人群25-(OH)D缺乏率高,血清25-(OH)D水平与TC和TG存在负相关。Objective To explore the association between 25-hydroxy vitamin D[25-(OH)D]and serum lipid in health check-up subjects of a unit in Hefei city.Methods A total of 810 subjects were enrolled from a unit of Hefei city which underwent health examination in Health Management Center of the First Affiliated Hospital of Anhui Medical University.Serum 25-(OH)D,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were collected in May 2016.Pearson correlation and multiple linear regression were used to analyze the relationship between 25-(OH)D and serum lipid.Results The average level of 25-(OH)D was(15.81±4.87)ng/mL.80.6%subjects had vitamin D deficiency,with 13.0% severely deficient.Pearson correlation analysis showed that 25-(OH)D had a significant negative correlation with TC,lgTG,HDL-C.Multivariate linear regression analysis showed that 25-(OH)D were significantly negatively associated with TC(β=-0.015,95%CI=-0.029^-0.002,P=0.021)and lgTG(β=-0.008,95%CI=-0.011^-0.005,P<0.001).Conclu sions The rate of 25-(OH)D deficiency is high in health check-up subjects of a unit in Hefei city.25-(OH)D has a significant negative relationship with TC and TG.

关 键 词：25-羟维生素D 血脂 维生素D缺乏 体检 

分 类 号：R54[医药卫生—心血管疾病]