持续与无创葡萄糖监测技术的发展与应用  

Development and application of continuous and noninvasive glucose monitoring technology

作　　者：唐峻岭[1] 董璐[1] 王煜非[1] Tang Junling;Dong Lu;Wang Yufei(Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People′s Hospital,Shanghai Diabetes Institute,Shanghai Key Laboratory of Diabetes Mellitus,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病研究所,上海市糖尿病重点实验室,上海200233

出　　处：《中华检验医学杂志》2019年第11期914-918,共5页Chinese Journal of Laboratory Medicine

基　　金：科技部重大研发项目(2018YFC2000802)。

摘　　要：血糖监测是糖尿病治疗和管理过程中重要环节和手段。组织间液中的葡萄糖浓度与血液中葡萄糖浓度间存在高度相关性,实时监测组织间液葡萄糖浓度具有重要临床意义。持续葡萄糖监测(CGM)是一种新兴的血糖监测技术,以监测皮下组织间液葡萄糖水平来间接反映血糖水平,展现一段时间内连续、全面的血糖变化的信息和规律。CGM主要有3大类:微创植入式、无创微透式和无创检测式。无创血糖监测技术是未来发展方向,但准确度及与血糖数值延迟性将是临床应用需要克服的最大挑战。Blood glucose monitoring is an important part and means in the process of diabetes treatment and management.There is a high correlation between glucose concentration in interstitial fluid and glucose concentration in blood.Real-time monitoring of glucose concentration in interstitial fluid has important clinical significance.Continuous glucose monitoring(CGM)is an emerging glucose monitoring technology,which indirectly reflects the blood glucose level of the body through the glucose level in the interstitial fluid,providing continuous and comprehensive information and rules of blood glucose variation over a period of time.There are three main categories of CGM:minimally invasive implantation,non-invasive microtransparency and non-invasive technology.Noninvasive blood glucose monitoring technology is the future development direction,but accuracy and delay of blood glucose will be the biggest challenge to be overcome in clinical application.

关 键 词：血糖监测 持续葡萄糖监测 无创葡萄糖监测 

分 类 号：R58[医药卫生—内分泌]