载银配合物的制备及其抗菌与缓释性能研究  

Preparation and its antibacterial and sustained release properties of Ag-bio-MOF

作　　者：徐光年[1] 阮果连 朱继广 金俊成[1] Xu Guangnian;Ruan Guolian;Zhu Jiguang;Jin Juncheng(Technology Promotion Center of Nano Composite Material Preparation and Application,Anhui Provincial Laboratory of Biomimetic Sensor and Detecting Technology,West Anhui University,Lu'an 237012)

机构地区：[1]纳米复合材料制备与应用技术推广中心仿生传感与检测技术省级实验室皖西学院

出　　处：《化工新型材料》2019年第11期171-174,共4页New Chemical Materials

基　　金：安徽高校自然科学基金重点项目(KJ2015A286);国家级大学生创新创业项目(201710376001)

摘　　要：用自制的多孔配合物[Cd3(dpa)(DMF)2(H2O)3]·DMF(bio-MOF)为载体[其中dpa表示3,4-二(3,5-二羧基苯基)邻苯二甲酸,DMF为N,N-二甲基甲酰胺],硝酸银(Ag NO3)为前驱体,通过化学还原法制备了载银配合物(Ag-bio-MOF)。所制配合物的晶体结构分别采用X射线单晶衍射和X射线粉末衍射表征。通过佛尔哈德法测定Ag-bio-MOF中银含量为3. 3%(质量分数);通过去离子水反复浸泡,再用原子吸收光谱测水溶液中银离子的浓度确定银离子的缓释性能。结果表明,制备的Ag-bio-MOF最小抑菌浓度为50μg/m L,对大肠杆菌的灭菌率超过99%,且用去离子水连续浸泡5次后对大肠杆菌的灭菌率仍然大于99%,表明Ag-bio-MOF中的纳米银粒子具有良好的缓释性能。The silver loaded coordination polymer(Ag-bio-MOF) was synthesized by chemical reduction using the synthetic [Cd3(dpa)(DMF)2(H2O)3]·DMF(bio-MOF) as the carrier and Ag NO3 as precursor,then the structure of composite prepared were characterized by X-ray single crystal diffraction(XRSCD) and X-ray diffraction(XRD). The silver ions content loaded on composite was about 3. 3 wt% determined by Volhard method,and its sustained release property was determined by immersion of deionized water repeatedly. The minimum inhibition concentration(MIC) of the composite was50μg/m L and the sterilizing efficiency(SE) was over 99% against Escherichia coli ATCC 11229(E. coli). Moreover,the SE of supernatant to Escherichia coli was still more than 99% although after 5 times consecutive soaking by deionized water,indicating that Ag particles in/on the Ag-bio-MOF had an excellent sustained release performance.

关 键 词：纳米银 负载 配位聚合物 抗菌 缓释 

分 类 号：O64[理学—物理化学]