靛红亚胺参与构建手性3-氨基-2-吲哚酮骨架的研究进展  

Recent Progress on the Construction of Chiral 3-Amino-2-oxindoles Skeleton with Isatin-Derived Ketimines as Reactants

作　　者：张俊伟 吴昊 陈哲 金瑛 姜英子[1] ZHANG Junwei;WU Hao;CHEN Zhe;JIN Ying;JIANG Yingzi(Department of Pharmacy,Yanbian University,Yanji,Jilin 130000,China;Department of Pharmacy,Jilin Medical University,Jilin,Jilin 132013,China)

机构地区：[1]延边大学药学院,吉林延吉130000 [2]吉林医药学院药学院,吉林吉林132013

出　　处：《应用化学》2019年第12期1343-1360,共18页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(21102055);吉林省教育厅“十三五”科学技术项目(JJKH20180835KJ);吉林省卫生厅创新项目(2017J104)资助~~

摘　　要：手性3-氨基-2-吲哚酮骨架广泛存在于许多药物分子以及天然产物中,具有较高的药用价值。靛红亚胺参与的不对称反应是合成手性3-氨基-2-吲哚酮衍生物的直接途径。本文围绕着不对称aza-Henry反应、不对称环化反应及其他不对称反应3个方面,综述了靛红亚胺参与构建手性3-氨基-2-吲哚酮衍生物的研究进展并进行了展望。The chiral 3 amino 2 oxindole skeletons are widely present in many drug molecules and natural products and show high medicinal value. The asymmetric reaction involving of isatin derived ketimines provides a direct access to chiral 3 amino 2 oxindole derivatives. In this paper the recent progress on the asymmetric aza Henry cyclization and other asymmetric reactions for the construction of 3 amino 2 oxindoles skeleton with isatin derived ketimines is reviewed and the future development is prospected.

关 键 词：靛红亚胺 不对称 Aza-Henry 环化反应 3-氨基-2-吲哚酮 

分 类 号：O626.1[理学—有机化学]