8-异前列腺素F2α与氧化应激及过敏性紫癜关系的研究进展  

The research progress on the relationship between 8-iso-prostaglandin F2α,oxidative stress and Henoch-Schonlein purpura

作　　者：吴瑕(综述)[1] 张瑄(审校)[1] Wu Xia;Zhang Xuan(Department of Nephrology,Tianjin Children′s Hospital,Tianjin 300134,China)

机构地区：[1]天津市儿童医院肾内科,300134

出　　处：《国际儿科学杂志》2019年第11期794-796,共3页International Journal of Pediatrics

摘　　要：8-异前列腺素F2α是氧化应激状态下细胞膜脂质花生四烯酸发生脂质过氧化反应,经非酶途径β裂解重组而形成的稳定的终末产物,是评价脂质过氧化反应程度和损伤的理想指标。氧化应激可损伤生物分子,引起细胞死亡和组织损伤,其参与了过敏性紫癜及肾脏损害的过程。该文综述了机体氧化应激状态,脂质过氧化反应,8-异前列腺素F2α的产生及意义,氧化应激在过敏性紫癜发病及肾脏损害中的机制,以及测定8-异前列腺素F2α对于过敏性紫癜的重要临床意义,可为今后靶向治疗提供依据。8-iso-prostaglandin F2αis a stable end product of lipid peroxidation of cell membrane lipid arachidonic acid under oxidative stress,which is formed by non-enzymatic beta lysis and recombination.It is an ideal index for evaluating the degree of lipid peroxidation and damage.Oxidative stress can damage biological molecules,cause cell death and tissue damage,and participate in the process of Henoch-Schonlein purpura and kidney damage.This article reviews the oxidative stress state and lipid peroxidation process of the body,the production and significance of 8-iso-prostaglandin F2α,the mechanism of oxidative stress in the pathogenesis of Henoch-Schonlein purpura and renal damage,and the important clinical significance of measuring 8-iso-prostaglandin F2αfor Henoch-Schonlein purpura,which will provide evidence for future targeted therapy.

关 键 词：8-异前列腺素F2Α 氧化应激 过敏性紫癜 肾脏疾病 

分 类 号：R72[医药卫生—儿科]