HBV持续性感染致CD8^+T细胞耗竭的研究进展  

Study Progress in CD8^+T Cell Depletion Caused by Persistent HBV Infection

作　　者：梅清 李小鹏[2] 张伦理[2] MEI Qing;LI Xiao-peng;ZHANG Lun-li(Department of Ultrasound,Jingzhou Central Hospital,Jingzhou 434020,China;Department of Infectious Disease,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]荆州市中心医院超声科,湖北荆州434020 [2]南昌大学第一附属医院感染科,南昌330006

出　　处：《南昌大学学报（医学版）》2019年第5期84-87,共4页Journal of Nanchang University：Medical Sciences

基　　金：江西省自然科学基金(20161BAB205254、20161BAB205250);南昌大学研究生创新专项基金(CX2017239)

摘　　要：正常的特异性CD8^+T细胞能清除乙型肝炎病毒(HBV),但HBV的持续刺激将导致CD8^+T细胞耗竭。故CD8^+T细胞耗竭是慢性HBV持续性感染的重要特征之一,阻断CD8^+T细胞中抑制性分子的表达以逆转CD8^+T细胞耗竭是治疗慢性HBV感染非常有前景的策略。本文总结近年来通过阻断抑制性分子以达到逆转CD8^+T细胞耗竭的方法和作用机制,以期为慢性HBV感染的治疗提供参考。Normal specific CD8^+T cells can clear chronic hepatitis B virus(HBV).However,sustained HBV stimulation will result in the depletion of CD8^+T cells,which is one of the important characteristics of chronic HBV infection.As a promising strategy for the treatment of chronic HBV infection,blocking the expression of inhibitory molecules can reverse the depletion of CD8^+T cells.In order to provide a reference for the treatment of chronic HBV infection,this article summarizes the methods and mechanisms of blocking inhibitory molecules for reversing CD8^+T cell depletion.

关 键 词：乙型肝炎病毒 CD8^+T淋巴细胞 T细胞耗竭 免疫 

分 类 号：R512.6[医药卫生—内科学]