蒙药萨日嘎日迪联合西药治疗对2型糖尿病合并勃起功能障碍患者血清同型半胱氨酸和一氧化氮及一氧化氮合酶水平的影响  

Effect of Mongolia medicine Sarge Garidi combined with western medicine on serum homocysteine,nitric oxide and nitricoxide synthase in type 2 diabetic patients with erectile dysfunction

作　　者：段立志[1] 刘波[2] 张何英 尚国爱[1] 赵海霞 Duan Lizhi;Liu Bo;Zhang Heying;Shang Guoai;Zhao Haixia(Department of Endocrinology,Port Hospital,Heibei Port Group,CO.,LTD,Hebei Province,Qinhuangdao 066000,China;Department of Endocrinology,First Hospital of Qinhuangdao,Hebei Province,Qinhuangdao 066000,China;Department of Endocrinology,Mongolian Medicine Hospital of Horqin Right Wing Middle Banner,Inner Mongolia Autonomous Region,Hinggan League 029400,China)

机构地区：[1]河北港口集团有限公司港口医院内分泌科,河北省秦皇岛市066000 [2]河北省秦皇岛市第一医院内分泌科,066000 [3]科尔沁右翼中旗蒙医医院内分泌科,内蒙古自治区兴安盟029400

出　　处：《中国医药》2019年第12期1821-1825,共5页China Medicine

基　　金：河北省省级科技计划(152777117)~~

摘　　要：目的分析蒙药萨日嘎日迪联合西药治疗对2型糖尿病(T2DM)合并勃起功能障碍(ED)患者血清同型半胱氨酸(Hcy)、一氧化氮、一氧化氮合酶(NOS)水平的影响。方法选取2015年1月至2017年1月内分泌科住院治疗的346例T2DM合并ED患者作为研究对象,其中来自河北港口集团有限公司港口医院213例,内蒙古自治区科尔沁右翼中旗蒙医医院133例。应用随机数字表法将其分为观察组和对照组,每组173例。对照组在对症治疗基础上采用α-硫辛酸、前列地尔、甲钴胺治疗,观察组在对照组治疗基础上加服蒙药萨日嘎日迪治疗,2组患者均连续治疗2周。对2组患者治疗前后的国际勃起功能指数5(IIEF-5)评分、血清总睾酮及游离睾酮、Hcy、一氧化氮及NOS水平进行比较;观察治疗期间不良反应发生情况。结果 2组患者治疗前IIEF-5评分、血清总睾酮及游离睾酮、Hcy、一氧化氮及NOS水平差异均无统计学意义(均P> 0. 05)。经治疗后,2组IIEF-5评分、血清总睾酮及游离睾酮水平均较治疗前明显升高,且观察组明显高于对照组(均P <0. 05)。经治疗后,2组血清Hcy水平较治疗前明显降低,血清一氧化氮、NOS水平较治疗前明显升高[观察组:(8. 0±1. 0)μmol/L比(13. 3±1. 7)μmol/L、(36. 2±4. 6)μmol/L比(16. 6±2. 3)μmol/L、(35. 0±4. 2) k U/L比(19. 6±2. 7) k U/L;对照组:(9. 9±1. 2)μmol/L比(13. 2±1. 8)μmol/L、(29. 5±3. 8)μmol/L比(16. 6±2. 2)μmol/L、(29. 8±3. 8) k U/L比(19. 7±2. 8) k U/L];观察组治疗后的血清Hcy水平明显低于对照组,血清一氧化氮、NOS水平明显高于对照组,差异均有统计学意义(均P <0. 05)。2组不良反应发生率差异无统计学意义(P=0. 445)。结论在T2DM合并ED的治疗中,将蒙药萨日嘎日迪与α-硫辛酸、前列地尔、甲钴胺进行多药联合应用,能够更加明显地提升勃起功能和血清性激素水平,降低血清Hcy水平,改善血管内皮舒张功能,具有提高疗效的作�Objective To analyze the effect of Mongolia medicine Sarge Garidi combined with western medicine on serum homocysteine(Hcy),nitric oxide(NO)and nitricoxide synthase(NOS)in patients with type 2 diabetes mellitus(T2DM)complicated with erectile dysfunction(ED).Methods A total of 346 T2DM patients with ED were enrolled from January of 2015 to January of 2017 in Port Hospital,Heibei Port Group,CO.,LTD(213 patients)and Mongolian Medicine Hospital of Horqin Right Wing Middle Banner,Inner Mongolia Autonomous Region(133 patients).They were randomly divided into observation group and control group,with 173 cases in each group.The control group was treated withα-lipoic acid,alprostadil and mecobalamin on the basis of symptomatic treatment.The observation group took Sari Garidi on the basis of control group.Both groups were treated for 2 weeks.International Index of Erectile Function-5(IIEF-5),serum levels of total testosterone(TT),free testosterone(FT),Hcy,NO and NOS were determined before and after treatment.Adverse reactions were observed during treatment.Results There were no significant differences in IIEF-5 score,serum TT,FT,Hcy,NO and NOS levels between groups before treatment(all P>0.05).After treatment,IIEF-5 score,serum levels of TT and FT significantly increased in both groups and the indexes in observation group were significantly higher than those in control group(all P<0.05).Serum Hcy level significantly decreased and NO,NOS significantly increased after treatment[observation group:(8.0±1.0)μmol/L vs(13.3±1.7)μmol/L,(36.2±4.6)μmol/L vs(16.6±2.3)μmol/L,(35.0±4.2)k U/L vs(19.6±2.7)k U/L;control group:(9.9±1.2)μmol/L vs(13.2±1.8)μmol/L,(29.5±3.8)μmol/L vs(16.6±2.2)μmol/L,(29.8±3.8)k U/L vs(19.7±2.8)k U/L];Hcy level in observation group was significantly lower and NO,NOS were significantly higher than those in control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between groups(P=0.445).Conclusion Mongolia medicine Sarge Garidi combined withα-lipoi

关 键 词：2型糖尿病 勃起功能障碍 蒙药萨日嘎日迪 多药治疗 

分 类 号：R587.1[医药卫生—内分泌]