基于硼氮共掺杂荧光碳点定量分析吡罗昔康  

Quantitative Analysis of Piroxicam Based on Boron and Nitrogen Co-doped Fluorescent Carbon Dots

作　　者：吴青[1] 金星 王忠霞 王伟 WU Qing;JIN Xing;WANG Zhongxia;WANG Wei(Yancheng Third People's Hospital,Yancheng Jiangsu 224001,China;School of Chemistry and Chemical Engineering,Yancheng Institute of Technology,Yancheng Jiangsu 224002,China)

机构地区：[1]盐城市第三人民医院,江苏盐城224001 [2]盐城工学院化学化工学院,江苏盐城224002

出　　处：《盐城工学院学报（自然科学版）》2019年第4期31-37,共7页Journal of Yancheng Institute of Technology:Natural Science Edition

基　　金：国家自然科学基金项目(21575123)

摘　　要：以邻苯二胺、谷氨酸及硼酸为前驱体,通过简单的一步水热法成功制备水溶性极好的硼氮共掺杂荧光碳点(B,N-CDs)。该B,N-CDs粒径约为20 nm,在吡罗昔康(PRX)的存在下,由于B,N-CDs和PRX之间存在强烈的电子或能量转移导致发生了强烈的荧光淬灭效应。据此,应用荧光碳点B,N-CDs作为荧光探针成功构建了高选择性、高灵敏性的PRX检测荧光传感器。实验数据显示,该传感器具有响应速度快、线性范围宽和检测限低等优点。检测PRX的线性范围为2×10^-5~1.5×10^-4 mol/L,LOD为5.7×10^-8 mol/L。该传感器用于实际样品检测得到了较好的回收率(94.3%~103.3%),充分说明B,N-CDs在药物检测领域具有很好的潜在应用价值。Using o-phenylenediamine,glutamic acid and boric acid as precursors,B,N-CDs with excellent water solubility were successfully prepared by a simple one-step hydrothermal method.The particle size of B,n-CdS is about 20 nm.In the presence of piroxicam(PRX),strong electron or energy transfer between B,N-CDs and PRX results in strong fluorescence quenching effect.Based on this,a highly selective and sensitive PRX fluorescent sensor was successfully constructed by using fluorescent carbon point B,N-CDs as fluorescent probes.Experimental data show that the sensor has the advantages of fast response,wide linear range and low detection limit.The linear range of PRX was 2×10^-5~1.5×10^-4 mol/L and LOD was 5.7×10^-8 mol/L.The sensor has a good recovery rate(94.3%~103.3%)in the actual sample detection,which fully shows that B,N-CDs has a good potential application value in the field of drug detection.

关 键 词：硼氮共掺杂 碳材料 荧光 吡罗昔康 

分 类 号：O636.31[理学—高分子化学]