3种氟苯尼考产品在猪体内的药代动力学及相对生物利用度研究  

Study on the Pharmacokinetics and Relative Bioavailability of Florfenicol in Pigs

作　　者：李朋朋 张珍 李林育 张聪 晏磊 李召斌 张晓东 姚路路 杨绒娟 高艳艳 周德刚 LI Peng-peng;ZHANG Zhen;LI Lin-yu(National Research Center for Veterinary Medicine,Luoyang,Henan 471003)

机构地区：[1]国家兽用药品工程技术研究中心

出　　处：《安徽农业科学》2019年第24期125-127,142,共4页Journal of Anhui Agricultural Sciences

摘　　要：为比较不同氟苯尼考产品在猪体内的药代动力学和相对生物利用度,将18头健康猪随机分成3组,按照20 mg/kg体重经口给予受试制剂和参比制剂。采用高效液相色谱法测定血药浓度,使用WinNonlin软件计算主要药动学参数,并计算3种产品的相对生物利用度。结果表明,普得康、市售国产产品和市售进口产品的峰浓度(C max)分别为(13.46±1.26)、(13.68±2.55)和(13.33±1.02)μg/mL;达峰时间(T max)分别为(1.25±0.29)、(1.70±0.27)和(1.60±0.42)h;消除半衰期(t 1/2β)分别为(3.77±0.21)、(4.06±0.41)和(3.75±0.21)h;药时曲线下面积(AUC 0-t)分别为(93.07±7.00)、(84.58±11.13)和(90.89±7.99)h·μg/mL。以市售国产和进口产品作为对照药物,普得康的相对生物利用度(F)分别为110.0%和102.4%。这表明普得康主要药动学参数与2种市售产品相比无显著差异,此结论为临床合理使用该剂型提供了依据和指导。To compare the pharmacokinetics and relative bioavailability of different florfenicol products in pigs,18 healthy pigs were randomly divided into three groups and given respectively a single dose of test preparation or reference preparations(20 mg//kg)by oral ad ministration.The plasma concentrations of florfenicol were measured by HPLC.The main pharmacokinetic parameters were calculated by WinNonlin software,and the relative bioavailability of the three products was calculated.The results showed that the peak concentrations(C max)of Pudekang,commercially available domestic products,commercially available imported products were(13.46±1.26),(13.68±2.55)and(13.33±1.02)μg/mL respectively.Their peak time(T max)were(1.25±0.29),(1.70±0.27)and(1.60±0.42)h respectively.Their eli mination half-life(t 1/2β)were(3.77±0.21),(4.06±0.41)and(3.75±0.21)h respectively.And their AUC 0-t were(93.07±7.00),(84.58±11.13)and(90.89±7.99)h·μg/mL respectively.When two commercially available florfenicol products were used as reference preparations,the relative bioavailability(F)of test preparation(Pudekang)were 110.0%and 102.4%respectively.These results showed that there was no significant difference between main pharmacokinetic parameters of Pudekang and two commercially available florfenicol products.

关 键 词：氟苯尼考 猪 药代动力学 生物利用度 

分 类 号：S859[农业科学—临床兽医学]