孕期甲状腺功能减退及情绪障碍对不良妊娠结局的影响  

Effect of hypothyroidism and mood disorders during pregnancy on adverse pregnancy outcomes

作　　者：李琼 李海洋[1] 徐海耿[1] 芦金飞 张霞[1] 陈艳洁[1] LI Qiong;LI Haiyang;XU Haigeng;LU Jinfei;ZHANG Xia;CHEN Yanjie(Department of Obstetrics and Gynecology,Zhoushan Maternal and Child Health Hospital in Zhejiang Province,Zhoushan 316000,China;Department of Ultrasound,Zhoushan Maternal and Child Health Hospital in Zhejiang Province,Zhoushan 316000,China)

机构地区：[1]浙江省舟山市妇幼保健院妇产科,浙江舟山316000 [2]浙江省舟山市妇幼保健院超声科,浙江舟山316000

出　　处：《中国现代医生》2019年第32期51-54,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目（2017KY683）

摘　　要：目的探讨孕期甲状腺功能减退及情绪障碍对不良妊娠结局的影响。方法本研究采用回顾性分析的方法。选择2017年1月~2018年12月在我院分娩的合并甲状腺功能减退及情绪障碍的孕产妇100例为观察组,选择同期在我院孕期保健并且分娩的孕妇100例为对照组。统计两组孕产妇妊娠期高血压、妊娠期贫血、胎膜早破、早产、剖宫产率。统计围产儿不良结局,包括出生体重<2.5 kg、胎儿生长受限、先天性甲状腺功能减低、胎儿宫内窘迫、新生儿窒息。结果 (1)观察组妊娠期高血压(16.0%)、妊娠期贫血(12.0%)、剖宫产(35.0%)、早产(13.0%)、胎膜早破(16.0%)发生率显著高于对照组,差异有统计学意义(P<0.05)。(2)观察组出生体重<2.5 kg(10.0%)、胎儿生长受限(15.0%)、先天性甲状腺功能减低(6.0%)、胎儿宫内窘迫(13.0%)、新生儿窒息(9.0%)发生率均显著高于对照组,差异有统计学意义(P<0.05)。结论孕期甲状腺功能减退以及情绪障碍可增加不良妊娠结局。Objective To investigate the effect of hypothyroidism and mood disorders during pregnancy on adverse pregnancy outcomes. Methods Retrospective analysis method was used in the study. 100 cases of pregnant women with hypothyroidism and mood disorders who were delivered in our hospital from January 2017 to December 2018 were selected as observation group. And 100 pregnant women who underwent prenatal care and gave birth in our hospital were selected as control group. The gestational hypertension, gestational anemia, premature rupture of membranes, premature delivery, and cesarean section rate of two groups were counted. The adverse outcomes of perinatal infants were counted,including birth weight <2.5 kg, fetal growth restriction, congenital hypothyroidism, intrauterine distress, and neonatal asphyxia. Results(1)The incidence of gestational hypertension(16.0%), gestational anemia(12.0%), cesarean section(35.0%),premature delivery(13.0%), and premature rupture of membranes(16.0%) were significantly higher in the observation group than those in the control group, and the difference was statistically significant(P<0.05).(2)The incidence of birth weight<2.5 kg(10.0%), fetal growth restriction(15.0%), congenital hypothyroidism(6.0%), intrauterine distress(13.0%),neonatal asphyxia(9.0%) were significantly higher in the observation group than those in the control group, and the differ ence was statistically significant(P<0.05). Conclusion Hypothyroidism and mood disorders during pregnancy can increase adverse pregnancy outcomes.

关 键 词：孕期 甲状腺功能减退 情绪障碍 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]