泮托拉唑钠合成路线研究进展  

Research Progress on Synthesis Route of Pantoprazole Sodium

作　　者：陈辉[1] 林云良 李福伟 王兴民 刘玉智 郝翠 程燕 陈立宗 Chen Hui;Lin Yunliang;Li Fuwei;Wang Xingmin;Liu Yuzhi;Hao Cui;Cheng Yan;Chen Lizong(Shandong Analysis and Test Center,Qilu University of Technology(Shandong Academy of Science),Jinan 250014,China)

机构地区：[1]齐鲁工业大学(山东省科学院)山东省分析测试中心

出　　处：《山东化工》2019年第22期43-46,共4页Shandong Chemical Industry

基　　金：国家自然科学基金(21703126);山东省重点研发计划(2018GSF117006,2019GSF109063)

摘　　要：泮托拉唑钠是一种新型的H+/K+-ATP酶抑制剂,用于治疗返流性食道炎,胃溃疡和十二指肠溃疡等疾病,本文综述了以不同原料为起点的泮托拉唑钠合成路线,并讨论了各合成路线的优缺点。Pantoprazole sodium is a novel H+/K+-ATPase inhibitor for the treatment of diseases such as reflux esophagitis,gastric ulcer,and duodenal ulcer,etc.Starting from different raw materials,this paper reviews the synthetic routes of pantoprazole sodium,and discusses the advantages and disadvantages of each synthetic route.

关 键 词：泮托拉唑钠 合成 进展 

分 类 号：TQ463[化学工程—制药化工]