干细胞在喉软骨修复中的作用及研究进展  

Function and research progress of stem cells in laryngeal cartilage repair

作　　者：徐捷 沈志森[2] 吴益栋 崔翔 裘世杰 叶栋[2] XU Jie;SHEN Zhisen;WU Yidong;CUI Xiang;QIU Shijie;YE Dong(Medical School of Ningbo University,Ningbo,Zhejiang Province 315211;Department of Otorhinolaryngology?Head and Neck Surgery,Lihuili Hospital of Ningbo University,Ningbo,Zhejiang Province 315040)

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波大学附属李惠利医院耳鼻咽喉头颈外科,浙江宁波315040

出　　处：《北京生物医学工程》2019年第6期644-649,共6页Beijing Biomedical Engineering

基　　金：浙江省自然科学基金(LY19H160014、LY14H160003);浙江省医药卫生科技计划(2019ZD018、2014PYA017、2012ZDA042、2018RC063);宁波市自然科学基金(2012A610208、2017A610236);宁波市科技创新团队(2012B82019);宁波市重大择优委托项目(2012C5015);宁波市医疗卫生品牌学科(PPXK2018-02)资助

摘　　要：喉癌的发病率占头颈部恶性肿瘤的第二位并有上升趋势,手术后因喉组织缺损致喉呼吸、发音及吞咽等功能障碍,严重影响喉癌患者的生存率及生活质量。将组织工程支架用于喉相关疾病的治疗是较理想的方法之一,其中如何选择合适的种子细胞将其赋予支架中是非常重要的环节。干细胞作为种子细胞用于软骨修复已经证实优于分化的细胞如软骨细胞等,本文从喉软骨修复的国内外研究现状、干细胞的分类、干细胞修复软骨组织的作用机制等方面进行介绍,并分析了当前干细胞的相关研究进展及未来应用于临床的前景。Laryngeal cancer is the second leading cause of head and neck malignant tumors and is on the rise.The survival rate and life quality of patients are seriously affected after surgery.Tissue engineering scaffolds are one of the ideal methods for the treatment of laryngeal related diseases.It is the key point to select seed cells for tissue engineering scaffolds.Stem cells,as seed cells,have been proved to be superior to the differentiated cells such as chondrocytes in cartilage repair.In this paper,the research status of laryngeal cartilage repair at home and abroad,the classification of stem cells,and the mechanism of stem cells in cartilage tissue repair are introduced.The related research progress of stem cells is analyzed,and the future prospects for clinical application are also discussed.

关 键 词：喉软骨 干细胞 软骨修复 组织工程 支架 

分 类 号：R318[医药卫生—生物医学工程]