圆齿野鸦椿枝条化学成分及其抗炎活性研究  

Chemical Constituents and Anti-inflammatory Activity from the Twigs of Euscaphis konishii Hayata

作　　者：陈景新 詹玉莹 陈燕 徐会有[1] 邹双全[2] 倪林[1,2] CHEN Jingxin;ZHAN Yuying;CHEN Yan;XU Huiyou;ZOU Shuangquan;NI Lin(College of Plant Protection,Fujian Agriculture and Forestry University,Fuzhou 350002,China;Fujian Colleges and Universities Engineering Research Institute of Conservation&Utilization of Natural Bioresources,Fujian Agriculture and Forestry University,Fuzhou 350002,China)

机构地区：[1]福建农林大学植物保护学院,福建福州350002 [2]自然生物资源保育利用福建省高校工程研究中心,福建农林大学,福建福州350002

出　　处：《林产化学与工业》2019年第6期88-94,共7页Chemistry and Industry of Forest Products

基　　金：国家自然科学基金资助项目(31700292)

摘　　要：对圆齿野鸦椿枝条化学成分进行研究,从中分离得到15个化合物,通过理化性质与波谱分析分别鉴定为1-(4-羟基-3-甲氧基苯基)-2[4-(4′-羟丙基)-2′-甲氧基苯氧基]-1,3-丙二醇(1),acernikol(2),罗汉松脂素-4-O-β-D-葡萄糖苷(3),罗汉松脂素-4′-O-β-D-葡萄糖苷(4), 2-[4-(1-羟丙基)-3-甲氧基苯氧基]-1,3-丙二醇(5), 5,7-二羟基-2-甲基色原酮(6), 5,7-二羟基-2-甲基色原酮-6-C-β-D-葡萄糖苷(7), 5,7-二羟基-2-甲基色原酮-8-C-β-D-葡萄糖苷(8),槲皮素-3-O-α-L-阿拉伯糖(9),没食子酸(10), 4-羟基-3-甲氧基苯甲醛(11),硬脂酸(12), 19α-羟基熊果酸(13),β-谷甾醇(14)和胡萝卜苷(15)。除化合物7、8、14和15外,其他化合物均为首次从该属植物中分离得到。抗炎活性评价结果显示:当浓度为10μmol/L时,化合物2和4对脂多糖诱导的小鼠巨噬细胞白介素-6的分泌抑制率分别为(63.4±7.1)%和(58.6±4.6)%,显示中等抑制活性,略低于阳性对照药地塞米松的(85.8±5.3)%。Fifteen compounds were isolated from the twigs of Euscaphis konishii Hayata.The structure of the compounds was identified by physico-chemical properties and spectral data, and the fifteen compounds were as follows:threo-1-(4-hdroxy-3-methoxyphenyl)-2[4-(4′-hydroxypropyl)-2′-methoxyphenoxy]-1,3-propanediol(1), acernikol(2), nortrachelogenin-4-O-β-D-glucopyranoside(3), nortrachelogenin 4′-O-β-D-glucopyranoside(4), 2-[4-(1-hydroxypropyl)-3-methoxyphenoxy]-1,3-propanediol(5), 5,7-dihydroxy-2-methylchromanone(6), isobiflorin(7), biflorin(8), quercetin-3-O-α-L-arabinose(9), gallic acid(10), 4-hydroxy-3-methoxy benzaldehyde(11), stearic acid(12), 19α-hydroxy ursolic acid(13), β-sitosterol(14), daucosterol(15).All compounds except 7, 8, 14, 15 were isolated from the plants of the genus E. konishii for the first time.The evaluation results of anti-inflammatory activity showed that the inhibition rates of lipopolysaccharide-induced murine IL-6 secretion by compound 2 and 4 were(63.4±7.1)% and(58.6±4.6)%, respectively, at the concentration of 10 μmol/L.The medium inhibitory activity was shown to be slightly lower than that of the positive control drug dexamethasone.

关 键 词：圆齿野鸦椿 化学成分 结构鉴定 白介素-6 

分 类 号：TQ35[化学工程]