K3PO4-Promoted Cyclopropanation of Electron-deficient Alkenes with 2-Bromo-1,3-Propanedione Compounds  

作　　者：CHEN Zhanguo WEN Ting HOU Dan 

机构地区：[1]Key Laboratory for Macromolecular Science of Shaanxi Province,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi'an 710119,P.R.China

出　　处：《Chemical Research in Chinese Universities》2019年第6期1002-1007,共6页高等学校化学研究（英文版）

基　　金：Supported by the Natural Science Foundation of Shaanxi Province,China(No.2009JM2001);the Innovation Foundation of Postgraduate Cultivation of Shaanxi Normal University,China(No.2008CXB009).

摘　　要：An easy and efficient method for the synthesis of multisubstituted cyclopropane derivatives from electron-deficicent alkenes with 2-bromo-1,3-propanedione compounds was described.For this method,ethylα-cyanocinnamate derivatives 1 andβ,β-dicyanostyrene derivatives 4 can all smoothly reacted with 2-bromo-1,3-propanedione compounds 2 to afford the corresponding multisubstituted cyclopropane derivatives 3 and 5 in good to excellent yields(up to 100%)promoted by anhydrous K3PO4 in DMF at room temperature,respectively.A possible mechanism of this reaction was proposed.Structures of all the products were confirmed by ^1H NMR,^13C NMR and HRMS.

关 键 词：CYCLOPROPANATION Multisubstituted CYCLOPROPANE DERIVATIVE Electron-deficicent ALKENE 2-Bromo-l 3-propanedione compound 

分 类 号：O62[理学—有机化学]