载抗结核药骨水泥的筛选、制备及物理性能测定  

Screening of bone cements loaded with antituberculosis drugs:preparation and determination of physical properties

作　　者：袁虎成 马文鑫[2] 王骞[3] 王自立[2] 雷建 梁强 孙光伟 马雪花 刘振 张小敏[1] 杜江华 Yuan Hucheng;Ma Wenxin;Wang Qian;Wang Zili;Lei Jian;Liang Qiang;Sun Guangwei;Ma Xuehua;Liu Zhen;Zhang Xiaomin;Du Jianghua(Ningxia Medical University f Yinchuan 750004,China;Department of Spinal Surgery,the General Hospital of Ningxia Medical University,Yinchuan 750004,China;Medical University of South Florida,Tapa 33612,USA;School of Materials,Beifang University of Nationalities,Yinchuan 750021,China)

机构地区：[1]宁夏医科大学,银川,750004 [2]宁夏医科大学总医院脊柱骨科,银川750004 [3]美国南佛罗里达大学,坦帕33612 [4]北方民族大学材料学院,银川750021

出　　处：《中华实验外科杂志》2019年第12期2260-2263,共4页Chinese Journal of Experimental Surgery

摘　　要：目的探究载抗结核药骨水泥的物理性能.方法实验组将10种抗结核药与4种骨水泥以1.5 g∶40.0 g、2.5 g∶40.0 g的配比混合,根据ISO 5833标准制备载药骨水泥标准试件80组共400个;对照组将4种骨水泥粉剂与其液相单体混合,制备标准试件4组共20个.分别测定其平均面团、凝固时间、平均最高温度及机械强度.结果乙胺丁醇(E)、吡嗪酰胺(Z)、链霉素(S)、卷曲霉素(C)、阿米卡星(A)、莫西沙星(M)1.5、2.5g组与Palacos R、Palacos MV、Simplex P混合,平均面团、凝固时间、平均最高温度及机械强度均符合ISO标准,且混合后20 min内即硬化;利福平(R)、异烟肼(H)、利福喷丁(Rt)、丙硫异烟胺(P)1.5、2.5g组与上述骨水泥混合,平均面团、凝固时间均>ISO标准,平均最高温度明显低于对照组,机械强度均<ISO标准,硬化时间显著延长.10种药与CEMEX XL混合,物理性能及机械强度均<ISO标准.对照组间压缩强度比较,差异无统计学意义(F=3.470,P>0.05);弯曲强度及弯曲模量比较,差异有统计学意义(P<0.01).Palacos R及Simplex P骨水泥物理性能均符合ISO标准.CEMEX XL弯曲强度及弯曲模量、Palacos MV弯曲模量均<ISO标准.结论(1)Z、E、S、C、M、A的1.5、2.5g组分别与Palacos R、Palacos MV、Simplex P混合适于制备载药骨水泥;(2)R、H、Rt、P的1.5、2.5g组不适于制备载药骨水泥;(3)CEMEX XL骨水泥不适于载药.Objective To explore the physical properties of bone cements loaded with atituberculosis drugs.Methods We mixed ten drugs with four bone cements by 1.5 g:40.0 g and 2.5 g:40.0 g,400 modules of 80 groups were maded according to the ISO.The control group mixed bone cements with their liquid monomer,20 modules of 4 groups were maded.The physical properties were measured respectively.Results Group 1.5 g and 2.5 g of E,Z,S,C,A,M mixed with Palacos R,Palacos MV,Simplex P,the average dough time,solidification time,maximum temperature and mechanical strength were all meet ISO,and hardened in 20 minutes after mixing.Group 1.5 g and 2.5 g of R,H,Rt,and P mixed with the bone cements above,the average dough time,solidification time were all>ISO,the average maximum temperature was<the control group,the mechanical strength was<ISO,and the hardening time was significantly prolonged.The ten kinds of drugs mixed with CEMEX XL,the physical and mechanical strength were<ISO.There was no difference in compressive strength(F=3.470,P>0.05)between the four kinds of bone cements.The flexural strength and flexural modulus(P < 0.01)were different.The physical properties of Palacos R and Simplex P bone cements meet ISO.The flexural strength and flexural modulus of CEMEX XL bone cement were<ISO,and Palacos MV bone cement flexural modulus<ISO.Conclusion(1)Antituberculosis drugs Z,E,S,C,M,and A were suitable for preparing bone cements.(2)Antituberculosis drugs R,H,Rt,and P were not suitable for preparing bone cements.(3)CEMEX XL were not suitable for drug loading.

关 键 词：抗结核药 骨水泥 筛选 物理性能 

分 类 号：R52[医药卫生—内科学]