血清同型半胱氨酸及胱抑素C水平与冠状动脉病变程度的相关性研究  

Correlation among serum homocysteine,cystatin C levels and severity of coronary artery disease

作　　者：刘静[1] 张铁亮 黄定[1] 戴远辉 LIU Jing;ZHANG Tie-liang;HUANG Ding;DAI Yuan-hui(Second Department of Coronary Heart Disease,The First Affiliated Hospital of Xinjiang Medical University,Wulumuqi,Xinjiang,830054,China)

机构地区：[1]新疆医科大学第一附属医院冠心病二科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院影像中心放射科,新疆乌鲁木齐830054

出　　处：《心血管康复医学杂志》2019年第6期706-709,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：新疆维吾尔自治区自然科学基金青年项目(2018D01C219)~~

摘　　要：目的:分析血清同型半胱氨酸(Hcy)及胱抑素C(CysC)水平与冠状动脉病变程度的相关性。方法:选择2015年9月~2017年12月我院的冠心病(CHD)患者220例为CHD组,根据Gensini评分CHD组再分为轻度狭窄组(63例)、中度狭窄组(71例)和重度狭窄组(86例);以同期健康者200例为健康对照组。检测比较各组血清Hcy、CysC水平,并分析冠脉病变程度与血清Hcy、CysC水平的相关性。结果:与健康对照组比较,CHD组血清Hcy[(8.29±1.02)μmol/L比(16.14±3.01)μmol/L]、CysC[(0.65±0.11)mg/L比(1.21±0.12)mg/L]水平均显著升高,P均=0.001。与轻度狭窄组比较,中度狭窄组、重度狭窄组血清Hcy[(9.31±1.12)μmol/L比(12.13±3.32)μmol/L比(14.61±3.82)μmol/L]、CysC[(1.05±0.21)mg/L比(1.51±0.52)mg/L比(3.42±1.01)mg/L]水平均显著升高,且重度狭窄组的显著高于中度狭窄组的,P均=0.001。Pearson相关分析显示,血清Hcy(r=0.431,P=0.004)、CysC(r=0.640,P=0.003)水平与Gensini评分呈显著正相关。结论:血清Hcy及CysC水平与冠脉病变程度密切相关,其检测有助于对CHD患者疗效及预后的评估。Objective:To analyze correlation among serum homocysteine(Hcy),Cysteine C(CysC)levels and severity of coronary artery disease.Methods:A total of 220 coronary heart disease(CHD)patients treated in our hospital from Sep 2015 to Dec 2017 were selected as CHD group.According to Gensini score,CHD group were divided into mild stenosis group(n=63),moderate stenosis group(n=71)and severe stenosis group(n=86).Another 200 healthy people were enrolled as healthy control group.Serum Hcy and CysC levels were measured and compared among all groups.Correlation among serum Hcy,CysC levels and severity of coronary artery disease were analyzed.Results:Compared with healthy control group,there were significant rise in serum Hcy[(8.29±1.02)μmol/L vs.(16.14±3.01)μmol/L]and CysC[(0.65±0.11)mg/L vs.(1.21±0.12)mg/L]levels in CHD group.P=0.001 all.Compared with mild stenosis group,there were significant rise in serum Hcy[(9.31±1.12)μmol/L vs.(12.13±3.32)μmol/L vs.(14.61±3.82)μmol/L]and CysC[(1.05±0.21)mg/L vs.(1.51±0.52)mg/L vs.(3.42±1.01)mg/L]levels in moderate stenosis group and severe stenosis group,and those of severe stenosis group were significantly higher than those of moderate stenosis group,P=0.001 all.Pearson correlation analysis indicated that serum Hcy(r=0.431,P=0.004),CysC(r=0.640,P=0.003)levels were significant positively correlated with Gensini score.Conclusion:Serum Hcy and CysC levels is closely correlated with severity of coronary artery disease.Its detect is help for therapeutic effect and prognosis assessment for CHD patients.

关 键 词：冠心病 高半胱氨酸 半胱氨酸蛋白酶抑制剂 

分 类 号：R541.409[医药卫生—心血管疾病]