惠州地区妇女高危型人乳头瘤病毒感染特征及相关因素研究  

Study on characteristics and related factors of high-risk human papillomavirus infection in women in Huizhou city

作　　者：钟继生[1] 毛毅影 梁罕超[1] 杨桂春[1] 周福深 ZHONG Ji-Sheng;MAO Yi-Ying;LIANG Han-Chao(The Second Maternal and Child Health Care Hospital of Huizhou City,Huizhou,Guangdong 516001,China)

机构地区：[1]惠州市第二妇幼保健院

出　　处：《中国妇幼保健》2019年第23期5369-5372,共4页Maternal and Child Health Care of China

基　　金：惠州市科技计划项目(20160806)

摘　　要：目的调查惠州地区妇女高危型人乳头瘤病毒(HPV)感染情况,分析HPV感染的相关因素。方法随机选取2013年6月-2016年12月接受健康体检的3000例宫颈高危型HPV检查者,采集宫颈上皮细胞,采用基因芯片技术进行HPV检测。发放自制的《人乳头瘤病毒感染相关因素调查表》进行问卷调查,汇总分析妇女高危型人乳头瘤病毒感染特征及相关因素。结果3000例中高危型HPV感染率为18.3%,共检测出13种亚型,其中16型的检出率最高,占25.08%,其次为18、35及52型,检出率分别为16.72%、13.38%及13.71%,这几种亚型检出率明显比其他9种亚型高。20~35岁为阳性率最高的年龄段,随着年龄的增长HPV感染率明显下降。多因素统计分析结果显示多个性伴侣、性交出血及阴道分泌物增多的妇女高危型HPV感染的检出率相对较高,分别为84.85%、66.50%及51.15%,与其他因素相比差异具有统计学意义(P<0.05),其次为宫颈糜烂、孕产次数多及腰骶酸痛的人群,检出率分别为22.91%、21.07%及17.81%,比较其他因素差异也有统计学意义(P<0.05)。结论惠州地区妇女高危型HPV的感染率处在相对较高的水平,多个性伴侣、孕产次数多是感染高危型HPV的危险因素,对于性交出血、阴道分泌物增多、宫颈糜烂及腰骶酸痛等临床症状要重视,合并高危型HPV感染的概率较高,应积极进行相关检查和治疗。Objective To survey the infection status of high-risk human papillomavirus(HPV)among the women in Huizhou,analyze the related factors.Methods A total of 3000 women with high-risk HPV infection undergoing healthy physical examination from June 2013 to December 2016 were randomly selected,gene chip technology was used to detect HPV.A self-designed HPV infection-related factors questionnaire was used to survey the women,the characteristics and related factors of high-risk HPV infection were summarized and analyzed.Results The infection rate of high-risk HPV was 18.3%,13 HPV subtypes were detected,the detection rate of HPV 16 was the highest(25.08%),followed by HPV 18,HPV 35,and HPV 52(16.72%,13.38%,13.71%),the detection rates of HPV 16,HPV 18,HPV 35,and HPV 52 were higher than those of the other HPV subtypes.The positive rate of HPV was the highest among the women aged20-35 years old,which decreased with age.Multivariate analysis showed that the detection rates of high-risk HPV infection were high in the women with multiple sexual partners,sexual intercourse bleeding,increased vaginal secretion,which were 84.85%,66.50%,and51.15%,respectively,compared with other factors,there were statistically significant differences(P<0.05),followed by the women with cervical ectopic columnar epithelium,many times of pregnancy and delivery,and lumbosacral pain,which were 22.91%,21.07%,17.81%,respectively,compared with other factors,there were statistically significant differences(P<0.05).Conclusion The infection rate of high-risk HPV in Huizhou is high,multiple sexual partners and many times of pregnancy and delivery were risk factors of high-risk HPV infection,more attention should be paid to clinical symptoms,such as sexual intercourse bleeding,increased vaginal secretion,cervical ectopic columnar epithelium,and lumbosacral pain,the women with above-mentioned clinical symptomes have high infection rate of highrisk HPV,relevant examination and treatment should be actively carried out.

关 键 词：人乳头瘤病毒 高危型 感染特征 危险因素 

分 类 号：R7I1[医药卫生—临床医学]