深圳主要水体中20种抗生素药物分布特征  

Determination and Distribution Characteristics of 20 Antibiotics in Major Rivers and Bays of Shenzhen

作　　者：李可[1] 李学云[1] 丘汾[1] 周志峰[1] 梁肇海[1] LI Ke;LI Xueyun;QIU Fen;ZHOU Zhifeng;LIANG Zhaohai

机构地区：[1]广东省深圳市福田区疾病预防控制中心

出　　处：《环境卫生学杂志》2019年第5期455-461,共7页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：深圳市卫生计生系统科研顼目(201502015);深圳市福田区卫生公益性科研项目(FTWS2015001)

摘　　要：目的调查20种常见抗生素在深圳地区10条河流和深圳湾的污染状况,分析其分布特征。方法建立并使用超高效液相色谱串联质谱(UPLC-MS/MS)法对77个样品进行检测。结果14种抗生素在样品中均有检出,检出浓度最高的3种抗生素分别为磺胺甲恶唑、土霉素和呋喃西林。检出频次最高的依次为磺胺甲恶、氯霉素和磺胺甲氧嘧啶。布吉河、深圳河和观澜河受抗生素污染较为严重,并呈现出冬季(枯水期)明显高于夏季(丰水期)的季节性特征。75%的河流以3种及以上多种抗生素联合污染为主,磺胺类、四环素类和氯霉素类是优势药物。结论深圳地区水体中存在14种抗生素残留污染,整体污染处于较低水平。Objectives To investigate the pollution situation of 20 common antibiotics from ten rivers and Shenzhen Bay in Shenzhen,and analyze their distribution characteristics.Methods An analytical method was developed and adopted to determine 77 samples using ultra-high performance liquid chromatography/tandem mass spectrometry(UPLC-MS/MS).Results 14 antibiotics were delermined in samples.The detection concentrations of sulfamethoxazole(SMX),oxytetracycline(OXY),and nitrofarazone(NFZ)were the highest.The determination frequencies of sulfamethoxazole(SMX),chloramphenicol,sulfameter were the highest.The Buji River,Shenzhen River,Guanlan River were severely polluted by antibiotics and showed a seasonal variation feature of higher antibiotics concentration in winter(dry season)and lower concentrations in summer(wet season).75%of rivers were jointly polluted by three or moreantibiotics,in which,sulfonamide,tetracycline and chloramphenicol were predominant.Conclusions In Shenzhen,14 antibiotics pollution residuals existed in water bodies,and the overall pollution is in a relatively lower level.

关 键 词：抗生素 河流 深圳湾 

分 类 号：R123[医药卫生—环境卫生学]