七、八元瓜环与3-氨基香豆素的主客体相互作用  

Host-guest interaction of cucurbit [n=7,8] uril with 3-aminocoumarin

作　　者：黄净净 谢军 陶朱[1] 周清娣[2] 张前军[1] 卫钢 HUANG Jing-jing;XIE Jun;TAO Zhu;ZHOU Qing-di;ZHANG Qian-jun;WEI Gang(Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guiz houProvince,Chemistry and Chemical Engineering College,Guizhou University,Guiyang 550025,China;College of Chemistry,The University of Sydney,Sydney 2006,Australia;CSIRO Materials Science and Engineering,POBox 218,Lindfield 2070,Australia)

机构地区：[1]贵州省大环化学及超分子化学重点实验室,贵州大学化学与化工学院,贵州贵阳550025 [2]澳大利亚悉尼大学化学学院,新南威尔士州悉尼2006 [3]澳大利亚联邦科学与工业组织(CSIRO),新南威尔士州林德菲尔德2070

出　　处：《化学研究与应用》2019年第12期2055-2063,共9页Chemical Research and Application

基　　金：教育部春晖计划项目(Z2015003)资助

摘　　要：利用紫外-可见吸收光谱法、荧光光谱法、等温量热滴定法和核磁共振波谱法考察了七、八元瓜环(Q[7]、Q[8])与3-氨基香豆素(3-AC)之间的主客体相互作用。结果表明Q[7]与3-AC在pH=1.03的条件下形成包结比为1∶1的主客体配合物,紫外-可见吸收光谱和荧光吸收光谱测得的主客体包结稳定常数分别为3.789×10^4 L·mol^-1、4.136×10^4 L·mol^-1;Q[8]与3-AC在pH=1.03~6.97条件下均形成包结比为1∶1的主客体配合物,在中性条件下,紫外-可见吸收光谱和荧光吸收光谱测得的主客体包结稳定常数分别为2.551×10^5 L·mol^-1、2.455×10^5 L·mol^-1。其包结模式为3-氨基香豆素分子完全进入Q[7]或Q[8]分子空腔,主客体相互作用过程主要由焓和熵驱动。相溶解度法研究表明Q[7]、Q[8]的介入使3-AC在水中的溶解度分别增加了1.26倍和2.04倍。The host-guest interaction between cucurbit[n=7,8]uril(Q[7],Q[8])and 3-aminocoumarin(3-AC)was investigated by ultraviolet-visible(UV-Vis)absorption spectrometry,fluorescence spectroscopy,ITC and 1HNMR.The results showed that Q[7]and 3-Aminocoumarin formed an inclusion complex with a molar ratio of 1∶1 in pH=1.03.The host-guest inclusion stability constants measured by UV-Vis absorption and fluorescence absorption spectra were 3.789×10^4 L·mol^-1,4.136×10^4 L·mol^-1 respectively.Q[8]and 3-Aminocoumarin formed an inclusion complex with a molar ratio of 1∶1 in pH=1.03~6.97.The host-guest inclusion stability constants measured by UV-Vis absorption and fluorescence absorption spectra were 2.551×10^5 L·mol^-1,2.455×10^5 L·mol^-1 in neutral conditions respectively.The inclusion mode was that the 3-AC molecule enteredinto the cavity of Q[7]or Q[8]completely.The host-guest interactionprocess was mainly driven by enthalpy and entropy.Phase solubility measurements showed that the involvement of Q[7]and Q[8]increased the solubility of 3-AC in water by 1.26 and 2.04 fold,respectively.

关 键 词：七、八元瓜环 3-氨基香豆素 主客体包结配合物 

分 类 号：O657.3[理学—分析化学]