妊娠期糖尿病患者脂肪细胞因子与TLR4/MyD88信号通路相关蛋白的关系研究及临床意义  

Relationship between adipocytokines and TLR4/MyD88 signaling pathway-related proteins in gestational diabetes mellitus

作　　者：郭志利[1] 姚玉英[2] 姚克青 张梅[4] 于洪斌 苗莉娜[1] 王茹 尹晓琳[6] GUO Zhi-Li;YAO Yu-Ying;YAO Ke-Qing;ZHANG Mei;YU Hong-Bin;MIAO Li-Na;WANG Ru;YIN Xiao-Lin(Department of Microbiology and Immunology of Shijiazhuang Medical College,Shijiazhuang 050599,China)

机构地区：[1]石家庄医学高等专科学校微生物学和免疫学教研室,石家庄050599 [2]石家庄医学高等专科学校解剖学教研室,石家庄050599 [3]北京市朝阳区桓兴肿瘤医院肿瘤内科,北京100000 [4]石家庄科技信息职业学院中医内科,石家庄050000 [5]中国人民解放军白求恩国际和平医院妇产科,石家庄050000 [6]河北医科大学免疫教研室,石家庄050017

出　　处：《中国免疫学杂志》2019年第23期2908-2910,共3页Chinese Journal of Immunology

基　　金：2014年河北省省级科技计划项目(No.H2014206212)

摘　　要：目的:探讨妊娠期糖尿病患者脂肪细胞因子与TLR4/MyD88信号通路相关蛋白的关系研究。方法:选取2015年2月~2017年12月于中国人民解放军白求恩国际和平医院诊断治疗的妊娠期糖尿病患者,共计79例为研究对象,分析脂肪细胞因子与TLR4/MyD88信号通路相关蛋白的相关性。结果:经Pearson法分析,结果显示脂肪细胞因子和TLR4/MyD88信号通路相关蛋白表达具有相关性(P<0.05);TLR4、MyD88、TRAF-6、NF-κB、IL-1β均与FBG、PBG以及HOMA-IR相关联(P<0.05)。结论:妊娠期糖尿病患者可分泌大量脂肪细胞因子,且脂肪细胞因子与TLR4/MyD88信号通路相关蛋白均可能参与病情进展。Objective:To investigate the relationship between adipocytokines and TLR4/MyD88 signaling pathway-related proteins in gestational diabetes mellitus.Methods:A total of 79 patients with gestational diabetes mellitus who diagnosed and treated in China People′s Liberation Army Bethune International Peace Hospital from February 2015 to December 2017 were selected as the subjects and defined as the observation group.The correlation between adipocytokines and TLR4/MyD88 signaling pathway related proteins was analyzed.Results:Analysis by Pearson method,the results showed that there was a correlation between adipocytokines and TLR4/MyD88 signaling pathway-related protein expression(P<0.05);TLR4,MyD88,TRAF-6,NF-κB and IL-1βwere all associated with FBG,PBG and HOMA-IR(P<0.05).Conclusion:The patients with gestational diabetes can secrete a large number of adipocytokines,and both the adipocytokines and TLR4/MyD88 signaling pathway related proteins may participate in the progression of the disease.

关 键 词：妊娠期糖尿病 脂肪细胞因子 髓样分化因子88 相关性 

分 类 号：R587.1[医药卫生—内分泌]