SRA数据库架构及二代测序数据共享  

Introduction of SRA(Sequence Read Archive) and next-generation sequencing data sharing

作　　者：李瑞华 田国祥[3] 郭晓娟[4] 李豹 张军 吕军 Li Ruihua;Tian Guoxiang;Guo Xiaojuan;Li Bao;Zhang Jun;Lv Jun(Department of Surgical Oncology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061)

机构地区：[1]西安交通大学第一附属医院肿瘤外科,西安710061 [2]西安交通大学医学部公共卫生学院,西安710061 [3]解放军总医院第七医学中心干四科,北京100700 [4]西安交通大学第一附属医院神经内科,西安710061 [5]西安交通大学第一附属医院临床研究中心,西安710061

出　　处：《中国循证心血管医学杂志》2019年第11期1281-1284,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：国家社会科学基金一般项目(16BGL183)

摘　　要：近年来,随着二代测序技术的迅猛发展,高通量测序数据也呈指数级增长,SRA(Sequence Read Archive)数据库是用于存储这些二代测序原始数据和比对信息的代表性数据库。SRA数据库建立至今,各项测序数据迅速累积,已囊括多个物种、多种应用,成为大规模二代测序数据库及高效率的测序数据存储、提取及共享的平台。该数据库目前持续更新并面向公众开放。本文将介绍SRA数据库的网站架构及测序原始数据提取方法。In recent years,with the rapid development of next-generation sequencing technology,highthroughput sequencing data has also grown exponentially.The SRA(Sequence Read Archive)database is a representative database for storing these next-generation sequencing raw data and comparison information.Since the establishment of the SRA database,the sequence data has accumulated rapidly.At present,a large-scale database involving multiple species and multiple applications has been formed,which has become a platform for efficient storage,extraction and sharing of sequencing data.The database is currently continuously updated and open to the public.This article will introduce the SRA database website architecture and sequencing raw data extraction method.

关 键 词：SRA数据库 二代测序 数据提取 

分 类 号：R4[医药卫生—临床医学]