血管紧张素转化酶抑制剂对高血压患者氧化应激水平及血管内皮功能的影响  

Effects of angiotensin-converting enzyme inhibitors on oxidative stress and vascular endothelial function in patients with hypertension

作　　者：陈勇 方汉云 潘建生 李碎朋 赵章银 CHEN Yong;FANG Hanyun;PAN Jiansheng;LI Suipeng;ZHAO Zhangyin(Department of Cardiology,the Second People′s Hospital of Yueqing,Yueqing,Zhejiang 325608,China)

机构地区：[1]浙江省乐清市第二人民医院心内科

出　　处：《重庆医学》2019年第23期4054-4056,4061,共4页Chongqing medicine

摘　　要：目的 探讨血管紧张素转化酶抑制剂(ACEI)对不同程度高血压患者氧化应激水平及血管内皮功能的影响。方法 选取该院2016年10月至2017年10月收治的高血压患者240例,分为观察组与对照组(各120例),两组Ⅰ、Ⅱ、Ⅲ级高血压患者各40例,观察组患者给予ACEI,对照组患者给予硝苯地平控释片,治疗28d。检测两组患者超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)、血清内皮素-1(ET-1)和一氧化氮(NO)水平,并观察心血管事件发生情况。结果 同组Ⅲ级高血压患者血清SOD水平明显低于Ⅰ、Ⅱ级高血压患者(P<0.05),同组Ⅲ级高血压患者血清AOPP水平明显高于Ⅰ、Ⅱ级高血压患者(P<0.05);治疗后,观察组各级高血压患者血清SOD水平均高于对应的对照组患者,血清AOPP水平均低于对应的对照组患者,差异均有统计学意义(P<0.05)。同组Ⅲ级高血压患者血清ET-1、NO水平明显高于Ⅰ、Ⅱ级高血压患者(P <0.05);治疗后,观察组各级高血压患者血清ET-1、NO水平均低于对应的对照组患者,差异有统计学意义(P<0.05)。观察组心力衰竭、心绞痛发生率均明显低于对照组(P<0.05)。结论 ACEI有助于抑制高血压氧化应激,改善血管内皮功能。Objective To investigate the effects of angiotensin-converting enzyme inhibitors(ACEI)on oxidative stress and vascular endothelial function in patients with different degrees of hypertension.Methods A total of 240 cases of patients with hypertension admitted to this hospital from October 2016 to October 2017 were divided into the observation group and the control group,120 cases in each group.There were 40 cases of hypertension patients with gradeⅠ,ⅡandⅢin each group.Patients in the observation group were given ACEI,while those in the control group were given nifedipine controlled-release tablets for 28 d.The levels of superoxide dismutase(SOD),advanced oxidation protein product(AOPP),serum endothelin-1(ET-1)and nitric oxide(NO)were measured,and the occurrence of cardiovascular events was observed.Results The serum SOD level in patients with gradeⅢhypertension was significantly lower than that in patients with gradeⅠandⅡhypertension(P<0.05),and the serum AOPP level in patients with gradeⅢhypertension was significantly higher than that in patients with gradeⅠandⅡhypertension(P<0.05).After treatment,the serum SOD levels of patients with different degrees of hypertension in the observation group were higher than those of patients in the corresponding control groups,and the serum AOPP levels were lower than those of patients in the corresponding control groups,with statistically significant differences(P<0.05).The levels of serum ET-1 and NO in patients with gradeⅢhypertension were significantly higher than those in patients with gradeⅠandⅡhypertension in the same group(P<0.05).After treatment,the serum levels of ET-1 and NO in patients with all degrees of hypertension in the observation group were lower than those in the corresponding control groups,and the differences were statistically significant(P<0.05).The incidence rates of heart failure and angina in the observation group was significantly lower than those in the control group(P<0.05).Conclusion ACEI can inhibit oxidative stress and im

关 键 词：高血压 血管紧张素酶抑制剂药 内皮 血管 氧化性应激 

分 类 号：R544.1[医药卫生—心血管疾病]