微重力对单核巨噬细胞效应的研究进展  

Advances in research on the effect of microgravity on mononuclear macrophages

作　　者：王重振(综述)[1] 袁树民(审核)[2] WANG Chongzhen;YUAN Shumin(Guangxi Key Laboratory of Diabetes System Medicine;Department of Microbiology,Guilin Medical College,Guilin,Guangxi 541004,China)

机构地区：[1]桂林医学院广西糖尿病系统医学重点实验室,广西桂林541004 [2]桂林医学院微生物学教研室,广西桂林541004

出　　处：《重庆医学》2019年第23期4093-4096,共4页Chongqing medicine

基　　金：广西自然科学基金项目（2015GXNSFBA139122）

摘　　要：太空中微重力对人体有许多不良影响,能造成贫血、骨质疏松、免疫抑制等病理改变。微重力对人体的影响,部分原因是微重力对人体细胞有直接作用。微重力对单核巨噬细胞生理有多方面影响,比如对单核巨噬细胞发育和增殖有抑制作用、对活化的单核巨噬细胞合成活性氧和促炎细胞因子有抑制作用、对单核巨噬细胞迁移能力有抑制作用、对单核巨噬细胞向破骨细胞分化有促进作用,微重力对单核巨噬细胞的这些效应都能间接影响人体健康。已有的研究揭示了微重力对单核巨噬细胞效应的一些分子机制,这些分子机制的阐明有助于发现对抗微重力不良细胞效应的药物靶标。Microgravity in space has many adverse effects on human body,which can cause pathological changes such as anemia,osteoporosis and immunosuppression.The effect of microgravity on the human body is partly due to the direct effect of microgravity on human cells.Microgravity has many effects on the physiology of mononuclear macrophages,such as inhibiting the development and proliferation of mononuclear macrophages,the synthesis of active oxygen and proinflammatory cytokines by activated mononuclear macrophages,the migration ability of mononuclear macrophages,and promoting the differentiation of mononuclear macrophages into osteoclast,which can indirectly affect human health.Previous studies have revealed some of the molecular mechanisms of microgravity on mononuclear macrophages effect,and the elucidation of these molecular mechanisms can help to find the drug targets that counteract the adverse effects of microgravity on cells.

关 键 词：失重 单核细胞 巨噬细胞 

分 类 号：R392[医药卫生—免疫学]