IVF胚停患者绒毛染色体及相关免疫指标分析  

Analysis of Chorionic Chromosomes and Related Immune Indicators in Patients with IVF Embryo Abortion

作　　者：张娱 许波[1] 郭楠 周桂香 李叶林[2] 孙晓科 吴莉[1] ZHANG Yu;XU Bo;GUO Nan(The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230001)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)生殖中心,230001 [2]安徽医科大学

出　　处：《临床输血与检验》2019年第6期575-579,共5页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：国家基金委自然科学基金青年项目(No.816013-53)资助

摘　　要：目的研究辅助生殖技术后胚胎停育患者绒毛染色体同年龄、胚停史及自身免疫性抗体之间的关系.方法回顾性分析2016年2月~2018年8月进行体外受精-胚胎移植(in vitro fertilization and embyro transplantation,IVF-ET)助孕术后孕早期胚胎停育行绒毛染色体检查的患者113例.同时检测患者抗核抗体(anti-nuclear antibody,ANA)、抗心磷脂抗体(anti-cardiolipin antibody,ACA)抗甲状腺过氧化物酶抗体(anti-thyroperoxidase,ATA)、抗甲状腺球蛋白抗体(anti-thyroglobulin,ATG).结果①113例患者染色体正常64例,染色体异常者49例;②35岁以上患者染色体异常率显著高于35岁以下患者(67.57%VS31.58%,P<0.0001);③既往有无胚停史、胚停次数与绒毛染色体异常之间并无显著联系;④染色体正常组中测出ACA、ANA、ATA/ATG阳性率虽高于染色体异常组,但差异不显著.结论随着年龄增加,染色体异常比例显著增高;既往有无胚停史与染色体是否异常之间并无显著联系.Objective To investigate the relationships between missed abortion and age,autoimmune antibody,the history of spontaneous abortion among women after invitro fertilization-embryo transfer(IVF-ET).Methods A retrospective analysis was made on 113 cases of chorionic chromosome examination in early abortion after IVF-ET from February 2016 to August 2018.Anti-nuclear antibody(ANA),anti-cardiolipin antibody(ACA),anti-thyroid peroxidase antibody(ATA)and anti-thyroglobulin antibody(ATG)were also detected.Results①64 patients had normal chromosomes in 113 cases.Chromosome abnormalities were found in 49 cases.②Chromosome abnormality rate of patients over 35 years old was significantly higher than that of patients under 35 years old(67.57%VS 31.58%,P<0.0001);③There was no significant correlation between the history or times of early abortion and the chromosomal abnormalities.④The positive rates of ACA,ANA and ATA/ATG in normal chromosome groups were higher than those in chromosomal abnormality groups,but without significant difference.Conclusion The rate of chromosome abnormalities increases with age.There is no significant relationship between the history of early abortion and the abnormalities of chorionic chromosomes after IVF-ET.

关 键 词：绒毛染色体 体外受精-胚胎移植 抗心磷脂抗体 抗核抗体 抗甲状腺过氧化物酶抗体 抗甲状腺球蛋白抗体 

分 类 号：R714.21[医药卫生—妇产科学]